A Rare Case of Esophageal Adenocarcinoma with Urinary Bladder Metastasis

Abstract

Metastatic esophageal adenocarcinoma to the urinary bladder is extremely rare. We describe a previously healthy 49-year-old female with recent diagnosis of adenocarcinoma of the gastroesophageal junction with metastatic disease to the liver. Biopsy was positive for human epidermal growth factor receptor 2 (HER2) by Fluorescence In Situ Hybridization (FISH). She received six cycles of Cisplatin, 5-Fluorouracil, and Herceptin and subsequently developed symptomatic anemia and hematuria. Cystoscopy with retroflexion was performed and she received a transurethral resection of bladder tumor with fulguration. Pathology of the bladder tumor revealed similar morphology to her liver metastasis and immunohistochemical stains were consistent with metastatic esophageal cancer. Three weeks after being diagnosed with metachronous urinary bladder metastasis from esophageal adenocarcinoma primary, she expired. She only received her first cycle of palliative chemotherapy with Ramucirumab and Paclitaxel.

A rare cause of ureteric stricture and hydronephrosis: metastatic esophageal cancer to the urinary bladder

“…This was diagnosed as part of staging of the esophageal cancer and was treated with palliative radiotherapy. Katz et al [8] in 2017 reported a patient with esophageal cancer and staging scan showed metastatic liver lesions with retroperitoneal adenopathy. She completed chemotherapy, but developed anaemia with hematuria and was subsequently found to have metastatic esophageal cancer to the bladder.…”