A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses

Kusafuka, Kimihide; Ito, Ichiro; Hirata, Keisuke; Miyamoto, Kazuya; Shimizu, Takeshi; Satomi, Hidetoshi; Inagaki, Hiroshi

doi:10.1007/s00795-021-00291-9

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…2), with a generally more complex genetic landscape, with RAS, PIK3CA, and TP53 alterations, similar to those reported for SDC (Table 1). 12,15,34,[39][40][41]44,50 This tumor type shows frankly destructive invasion frequently (41%), with a similar attendant loss of the myoepithelial layer, although definitive documentation of the myoepithelial layer representing part of the neoplasm (i.e., biphasic) has not yet been documented. In fact, it may be that the myoepithelial cells in apocrine-type tumors are not neoplastic.…”

Section: Nomenclature Developmentmentioning

confidence: 99%

“…If ever there was a need for better classification in salivary gland tumors, it would be for the tumor family represented by the term “intraductal carcinoma”(IDC). This critique will review the 183 cases reported (Table 1)1–50 by various terms over the years for this category of salivary gland neoplasm, and try to provide a framework for what is known, what requires further elucidation, and potential guidelines for naming conventions.…”

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confidence: 99%

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Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification

Thompson

Bishop

2022

Advances in Anatomic Pathology

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Salivary gland intraductal carcinoma (IDC) is a very uncommon group of neoplasms. Many names, variations in diagnostic criteria, and newly observed molecular findings (including NCOA4::RET, TRIM27::RET, HRAS point mutations, and PIK3CA pathway alterations) have generated further confusion in being able to recognize and categorize this group of tumors. Different histologic appearances and patterns of growth suggest there is more than one tumor category, with intercalated duct, apocrine, oncocytic, and hybrid features seen. Frankly destructive invasion further complicates the category, as the name "intraductal" would suggest an "in situ" neoplasm. Recent evidence on fusion-positive IDC demonstrates the same molecular underpinnings in both the ductal and the myoepithelial cells, which aids in further separating these tumors. This article summarizes the historical group of 183 neoplasms classified under the umbrella of IDC and highlights the unique histologic, immunohistochemistry, and molecular features that may further guide nomenclature standardization and harmonization.

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