A rare case of inflammatory pseudotumour of the bronchus, occurring in an achondroplastic woman

Vanderheyden, Marc; Meerbeeck, Jan Van; Bouwel, Erik Van; Bosmans, V; Colpaert, Cecile; Ramael, Marc; Marck, E. Van

doi:10.1183/09031936.94.07040826

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…As described previously in detail, this method allows quantification of tissue samples as low as 2-3 mg. 24 The tissue samples were fresh frozen in liquid nitrogen and stored at 280˚C. The frozen samples were thawed in 1 ml of Trizol solution and homogenised in a Polytron 3000 homogeniser at 30 000 rpm for 30 seconds.…”

Section: Myocardial Cytokine Gene Expressionmentioning

confidence: 99%

Myocardial cytokine gene expression is higher in aortic stenosis than in idiopathic dilated cardiomyopathy

Vanderheyden

Paulus²,

Voss³

et al. 2005

Heart

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Objective: To investigate cytokine gene expression in patients with aortic valve stenosis (AS) and with idiopathic dilated cardiomyopathy (DCM), and to correlate wall stress with myocardial proinflammatory cytokine gene expression. Methods: Human left ventricular (LV) myocardial biopsies were obtained for subsequent reverse transcription polymerase chain reaction of tumour necrosis factor a (TNFa), interleukin (IL) -1b, and IL-6 mRNA. The study population consisted of 24 patients with AS and 10 patients with idiopathic DCM. Results: Patients with AS had a larger ejection fraction (56 (5) v 37 (4)%, p , 0.01), smaller LV end diastolic volumes (146 (11) v 267 (21) ml, p , 0.01), and lower end systolic wall stress (44 (7) v 112 (11) kdyn/cm 2 , p , 0.001). Upregulation of TNFa, IL-1b, and IL-6 gene expression was detected in both groups. However, TNFa gene expression was significantly higher in AS than in DCM (p = 0.009). No correlation was found between haemodynamic parameters and TNFa gene expression. In patients with AS there was a strong inverse relation between circulating TNFa and TNFa gene expression (r = 20.685, p = 0.014), between circulating TNFa and IL-1b gene expression (r = 20.664, p = 0.018), and between soluble TNF receptor 2 and TNFa gene expression (r = 20.685, p = 0.020). Myocardial gene expression of TNFa was significantly higher in patients with well compensated AS than in patients with decompensated AS (p = 0.017). Similarly, patients with decompensated DCM were characterised by significantly lower TNFa gene expression than were patients with well compensated DCM (p = 0.011). Conclusion: TNFa gene expression is significantly higher in patients with pressure overload than in normal hearts, in patients with idiopathic DCM, and in patients with compensated versus decompensated heart failure. Secondly, in patients with AS proinflammatory cytokine gene expression did not affect systolic performance. The higher TNFa gene expression in patients with compensated heart failure suggests that cytokine gene expression has an adaptive role in the early phase of LV remodelling.

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Section: Myocardial Cytokine Gene Expressionmentioning

confidence: 99%

Myocardial cytokine gene expression is higher in aortic stenosis than in idiopathic dilated cardiomyopathy

Vanderheyden

Paulus²,

Voss³

et al. 2005

Heart

Self Cite

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“…3 Endobronchial growth is more often seen in the fibrous histiocytoma type. 4 Histologically, spindle-shaped mesenchymal cells (mostly myofibroblasts) and inflammatory cells (mostly plasma cells) confirm the diagnosis. Immunohistochemical staining for vimentin and smooth muscle actin is usually positive with consistent ultrastructural features.…”

Section: Discussionmentioning

confidence: 90%

“…3 Approximately 60% of these lesions occur in patients younger than 30 years, whereas it is the most common primary tumor-like lesion in children younger than 16 years. 4 IMTs may be asymptomatic because of their slow growth and peripheral tendency, but endobronchial and larger/invasive parenchymal lesions (with very rare rapid growth) may cause symptoms of cough, wheeze, dyspnea, and/or hemoptysis. Peripheral lesions tend to invade pleura, whereas central lesions more often invade hilar structures.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Left Main Stem Bronchus

Privitera

Hwang

Darling

2006

Journal of Thoracic Oncology

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Inflammatory myofibroblastic tumor (IMT) (pseudotumor) is a rare solid tumor that most commonly affects the lung. Its unknown etiology and cellular variability have resulted in inconsistent naming of this lesion. Treatment modalities have varied, but complete surgical resection seems to be most appropriate. We describe a 28-year-old woman with a near-obstructing IMT of the left main stem bronchus (LMB) treated with bronchial sleeve resection.

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