A rare case of intravascular schwannoma

Ward, Rachel Elizabeth; Shah, Julia A.; Mehregan, Darius

doi:10.1111/cup.13328

Cited by 3 publications

(15 citation statements)

References 7 publications

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“…Unlike the previous cases, the schwannoma in ours did not show a luminal location — even partially — to suggest a previous embolus. Also, features of an organized thrombus were not evidenced, contrary to what was seen in some of the other published cases …”

Section: Discussioncontrasting

confidence: 99%

“…The third case published in the literature also showed an intraluminal location of the schwannoma, without any horizontal extension into the blood vessel wall …”

Section: Discussionmentioning

confidence: 79%

“…There is a report of a schwannoma extending from the left atrium outside the atrial chamber . Also, three cases of intravascular (intraluminal) schwannomas have been previously described . In one of them, the tumor was entirely intravascular with a minimal wall attachment shown in their fig.…”

Section: Discussionmentioning

confidence: 97%

“…Nevertheless, in practice, schwannomas in certain locations are very rare. For instance, they have been only very rarely reported involving the blood vessels …”

Section: Introductionmentioning

confidence: 99%

“…For instance, they have been only very rarely reported involving the blood vessels. [1][2][3] So far, blood vessel schwannomas have only been described in an intravascular (intraluminal) location. [1][2][3] In contrast, herein we present the unique case of an intramural schwannoma arising in the wall of a subcutaneous vein.…”

Section: Introductionmentioning

confidence: 99%

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Intramural schwannoma involving a vein

Fernández-Flores

Saeb‐Lima

2018

J Cutan Pathol

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Schwannoma involving the blood vessels is a rare phenomenon. So far, only three cases of intravascular schwannoma have been described (all of which were intraluminal), and the origin of the schwannoma in such cases is not yet completely understood. Here, we describe a very rare intramural venous schwannoma in the subcutaneous right prepatellar area of a 31‐year‐old man. The schwannoma grew by enlarging and thickening the blood vessel wall, between two preserved layers of the vein. In some areas, there was erosion of the luminal layer, with fibrin apposed to the tumor. The tumor expressed S100 and was negative for CD31, CD34, desmin, and smooth muscle actin. The expression of p16 was preserved. Endothelial markers such as CD31 and Factor VIII showed the endothelial lining (which was D2‐40‐negative) above the tumor. Although degenerative atypia was present, there were no mitotic figures or necrosis identified.

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Section: Discussioncontrasting

confidence: 99%

“…The third case published in the literature also showed an intraluminal location of the schwannoma, without any horizontal extension into the blood vessel wall …”

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 97%

“…Nevertheless, in practice, schwannomas in certain locations are very rare. For instance, they have been only very rarely reported involving the blood vessels …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intramural schwannoma involving a vein

Fernández-Flores

Saeb‐Lima

2018

J Cutan Pathol

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Intravascular schwannoma: A review of a rare diagnosis

Dai

Cai

2020

J Cutan Pathol

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While schwannoma is one of the most common types of benign peripheral nerve tumors in adults, a very unique and specific variant of schwannoma, the intravascular variant, is exceedingly rare. There have only been three previously published cases of intravascular schwannomas. Here we describe a fourth case of an intravascular schwannoma in a 47‐year‐old man with an enlarging subcutaneous nodule on his posterior calf. This is the second case of an intravascular schwannoma contained within a vein. Also included is an overview of intravascular schwannomas, including a description and discussion of the histopathological diagnosis, differential diagnoses, and schwannoma variants.

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Intravascular schwannoma as an extremely unusual cause of vein obstruction: a case report

Chinchilla-Tábora,

Blázquez,

Sayagués

et al. 2024

J Pathol Transl Med

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The blood vessel lumen is an extremely rare location for a benign peripheral nerve sheath tumor like schwannoma. Less than 10 cases have been previously reported. In this report, we present a case of a 68-year-old woman who had a soft tissue nodule at the posterior calf of her left leg during a physical examination. Pathological examination was performed after complete surgical excision. The patient underwent follow-up for 12 months after surgery without evidence of recurrence or any other complication. This is the first case of intravascular schwannoma reported as a cause of vein obstruction. Microscopically, the tumor was composed of Schwann spindle cells that were immunoreactive for S100 protein and SOX10. This tumor was surrounded by a well-defined vascular smooth muscle wall. Prospective series are required to improve the knowledge on the underlying mechanisms of intravascular schwannoma development.

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A rare case of intravascular schwannoma

Cited by 3 publications

References 7 publications

Intramural schwannoma involving a vein

Intramural schwannoma involving a vein

Intravascular schwannoma: A review of a rare diagnosis

Intravascular schwannoma as an extremely unusual cause of vein obstruction: a case report

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