A rare case of iron-pill induced gastritis in a female teenager

Meliţ, Lorena Elena; Mărginean, Cristina Oana; Mocanu, Simona; Mărginean, Maria Oana

doi:10.1097/md.0000000000007550

Cited by 30 publications

(23 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A prompt diagnosis of these entities might prevent life-threatening complications such as peptic ulcer disease or gastric cancer, which develops after a long-time span of chronic gastric inflammation. [ 1 , 2 ]…”

Section: Introductionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

Self Cite

View full text Add to dashboard Cite

Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori ( H pylori ) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). We performed a prospective, case–control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case. Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1— H pylori -induced gastritis (31 patients) and group 2—non- H pylori- induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis ( P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR ( P > .05). However, significantly higher values of lymphocytes were associated with non- H pylori -induced gastritis ( P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results. Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non- H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.

show abstract

Section: Introductionmentioning

confidence: 99%

Pediatric gastritis and its impact on hematologic parameters

Săsăran

Meliţ

Mocan³

et al. 2020

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Contrariwise, other studies stated that leukocyte count and ESR were significantly higher especially in acute cases ( 14 ). The decrease in hemoglobin is a well-known marker of infection, but it can also occur in case of prolonged inflammation, acute hemorrhage or certain intoxications ( 9 , 25 – 27 ). Our patient presented a persistent elevated leukocyte count and an ESR of over 100 mm/h.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Mycoplasma pneumoniae and Chlamydia pneumoniae, a Life-Threatening Condition in Small Children—A Case Report and a Review of the Literature

et al. 2020

Self Cite

View full text Add to dashboard Cite

“…Liquid preparations may minimise gastrointestinal upset and avoid the risk of iron tablet-induced gastric erosion. 45,46 Co-administration of oral iron with ascorbic acid is advocated by some experts because of the theoretical enhancement of iron absorption by reduction of ferric iron to the ferrous form. 47 Indeed, oral ascorbic acid administration was associated with a dose-dependent increase of oral iron absorption in healthy volunteers.…”

Section: Route and Dosing Of Iron Replacement Therapymentioning

confidence: 99%

Joint recommendations on management of anaemia in patients with gastrointestinal bleeding in Hong Kong

Mak¹,

Wallis

Hui

et al. 2018

Hong Kong Med J

View full text Add to dashboard Cite

The demand for blood products continues to grow in an unsustainable manner in Hong Kong. While anaemia associated with gastrointestinal bleeding (GIB) is the leading indication for transfusion, there is no local recommendation regarding best practices for transfusion. We aimed to provide evidence-based recommendations regarding management of anaemia in patients with acute and chronic GIB. We reviewed all original papers, meta-analyses, systematic reviews, or guidelines that were available in PubMed. For acute GIB, a restrictive transfusion strategy, targeting a haemoglobin threshold of 7 to 8 g/dL, should be adopted because overtransfusion is associated with significantly higher all-cause mortality and re-bleeding. A liberal transfusion strategy should only be considered in patients with co-existing symptomatic coronary artery disease, targeting a haemoglobin threshold of 9 to 10 g/dL. When acute GIB settles, patients should be prescribed iron supplements if iron deficiency is present. For chronic GIB, iron stores should be replenished aggressively via iron supplementation before consideration of blood transfusion, except in patients with symptoms of severe anaemia. Oral iron replacement is the preferred first-line therapy, while intravenous iron is indicated for patients with inflammatory bowel disease, poor response or poor tolerability to oral iron, and in whom a rapid correction of iron deficit is preferred. Intravenous iron is underutilised and the risk of anaphylactic reaction to current preparations is extremely low. These recommendations are provided to local clinicians to facilitate judicious and appropriate use of red cell products and iron replacement therapy in patients with GIB.

show abstract

A rare case of iron-pill induced gastritis in a female teenager

Cited by 30 publications

References 16 publications

Pediatric gastritis and its impact on hematologic parameters

Pediatric gastritis and its impact on hematologic parameters

The Association Between Mycoplasma pneumoniae and Chlamydia pneumoniae, a Life-Threatening Condition in Small Children—A Case Report and a Review of the Literature

Joint recommendations on management of anaemia in patients with gastrointestinal bleeding in Hong Kong

Contact Info

Product

Resources

About