A rare case of KILT syndrome in Ireland: A case report

Bassa, Bibi Ayesha; Ryan, David P.; Reid, Emma; Bolster, Ferdia; Breslin, Tomás

doi:10.1016/j.tru.2023.100131

Cited by 1 publication

(3 citation statements)

References 23 publications

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“…All articles were published between 1998 and 2023. Sixteen articles were from Europe (four from the United Kingdom, 5,10,12,13 three from Italy, 14–16 three from Spain, 17–19 and one each from Belgium, 20 the Netherlands, 21 Switzerland, 22 Romania, 23 Slovakia, 24 and Poland 25 ), nine from North America (eight from the USA 26–33 and one from Canada 34 ), six from Asia (two from China 35,36 and one each from Japan, 37 Iran, 38 Jordan, 39 and the United Arab Emirates 40 ), and one from Australia. 41…”

Section: Resultsmentioning

confidence: 99%

“…29,33,40 Thrombosis was recurrent in nine patients (26.5% cases). In three patients, anticoagulation had already been stopped at the time of recurrence (after recurrence, long-term therapy was indicated in two patients, 13,30 and anticoagulation was not possible because of intracranial bleeding in others 26 ); for three patients, there were no data on anticoagulation treatment at the time of thrombosis. 17,19,20 Three patients – one on VKA, 22 one on LMWH with antithrombin concentrate, 24 and one on rivaroxaban – were still receiving treatment when recurrence was diagnosed.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of patients (76.5%) were treated with unfractionated heparin or LMWH, followed by vitamin K antagonists (VKA). Five patients, including the one reported here, received direct oral anticoagulants (DOAC; rivaroxaban, 29,35 apixaban, 13 and dabigatran 14 ). Additionally, in one patient, rivaroxaban and apixaban were tried after VKA failure (persistent symptoms, recurrence, and stent thrombosis), but without any success; therefore, the patient was treated with clopidogrel and enoxaparin.…”

Section: Resultsmentioning

confidence: 99%

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Deep venous thrombosis in patients with atresia of the inferior vena cava and right kidney hypoplasia (KILT syndrome): Systematic review of the literature

Pantic,

Cvetkovic,

Milin-Lazovic

et al. 2024

Vasc Med

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Inferior vena cava (IVC) anomalies are uncommon congenital causes of deep vein thrombosis (DVT). KILT syndrome (kidney and IVC abnormalities with leg thrombosis) has only been described as case reports in the literature. Therefore, the characteristics, evaluation, and management of patients with KILT syndrome have not yet been standardized. This study aimed to systematically review and analyze the clinical and radiographic data and treatment of previously reported cases of KILT syndrome. In this systematic review, we performed a literature search of the PubMed, Scopus, and Web of Science databases in December 2023, with no restrictions on the publication date. After duplicate extractions, 4195 articles were screened. Case reports and case series reporting on KILT syndrome were included. In addition to previously published cases, we included a new case of a previously healthy 25-year-old man with KILT syndrome in the analysis. A total of 34 cases were therefore included in this study. The majority (76.5%) were male patients with a median age of 24 years. In most patients, unprovoked bilateral iliofemoral thrombosis was diagnosed, and 64.7% had left kidney abnormalities. Our study suggests that anomalies of the IVC should be suspected in all young patients, especially male patients, with proximal, recurrent, or idiopathic DVT. If an IVC anomaly is confirmed, the kidneys should be examined to monitor and preserve healthy kidneys in cases of KILT syndrome. The data collected from all patients emphasize the requirement of long-term anticoagulation and risk factor control. Surgical measures may be effective for treating symptomatic refractory cases.

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