A rare case of lobular breast cancer metastasizing to large bowel

Yanagisawa, Waka; Krishnan, Sandra; Fernandez, A

doi:10.1002/ccr3.4081

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…In terms of breast cancer subtypes, invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) exhibit differences. While most invasive breast cancers consist of carcinomas of the ductal type, about 10% are invasive lobular carcinomas [26] and ILC is known to have distinct clinical and prognostic features and tends to metastasize to rare organs like the colon and other organs [5,27]. In our cohort, primary breast cancer pathology was IDC in 62% of cases and ILC in 38% of cases, which is higher than the prevalence of lobular carcinoma in the general breast cancer population [26].…”

Section: Discussionmentioning

confidence: 64%

Ocular and Periocular Metastasis in Breast Cancer: Clinical Characteristics, Prognostic Factors and Treatment Outcome

Yousef,

Mohammad,

Khalil

et al. 2024

Cancers

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Background: Breast cancer remains a leading cause of cancer-related mortality and morbidity worldwide. Ocular and periocular metastasis present as a rare but clinically significant manifestation. This study aims to explore demographics and clinical aspects of ocular and periocular metastasis in breast cancer patients. Methods: A retrospective cohort study comprising 45 breast cancer patients with ocular or periocular metastasis treated between 2013 and 2023. Patient demographics, tumor characteristics, diagnostic methods, treatment modalities, visual outcomes, and survival data were analyzed. Results: Among 9902 breast cancer patients, 0.5% developed ocular or periocular metastasis, constituting 2.4% of metastatic cases. The median age was 50 years. Ocular metastasis timing varied: 5% before breast cancer, 24% concurrent, 22% within a year, and 49% after. The most common presentations included incidental MRI findings (42%) and vision decline (31%). Metastasis involved the orbit (47%), choroid (40%), optic nerve (11%), and iris (2%), with 44% having bilateral involvement. Predictive factors included invasive lobular carcinoma (ILC) (p < 0.0001) and brain metastasis (p < 0.0001), with ILC exhibiting a sixfold higher likelihood of ocular metastasis than invasive ductal carcinoma (IDC). Primary treatment was radiation therapy (89%), yielding a 55% maintenance of excellent vision (<0.5), with 93% developing dry eye disease. Patients with ocular metastasis faced an increased risk of disease-related mortality (p < 0.0001), with 71% succumbing within 10 months post-diagnosis. Conclusions: Ocular metastasis in breast cancer is rare (0.5%) but signifies poor outcome. It is linked to ILC and concurrent brain metastasis. Primary treatment involves radiation therapy, with a favorable visual prognosis.

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Section: Discussionmentioning

confidence: 64%

Ocular and Periocular Metastasis in Breast Cancer: Clinical Characteristics, Prognostic Factors and Treatment Outcome

Yousef,

Mohammad,

Khalil

et al. 2024

Cancers

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“…Breast cancer metastases to the GI tract are rare. However, ILC has a predilection to spread to the GI tract in 5% of cases, compared to 0.2% in IDC [ 5 ]. The most common site of GI spread is the stomach, followed by the small bowel and colorectum.…”

Section: Discussionmentioning

confidence: 99%