A Rare Case of Malignant Solitary Fibrous Tumor of the Spinal Cord

Muñoz, Eva; Prat, Aleix; Adamo, Bárbara; Peralta, Sergio; Cajal, Santiago Ramón y; Valverde, Claudia

doi:10.1097/brs.0b013e31817343dc

Cited by 56 publications

(51 citation statements)

References 13 publications

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“…The 2 cases of solitary fibrous tumor arose from different sites: 1 was an intracranial solitary fibrous tumor (hemangiopericytoma) and the other was a renal solitary fibrous tumor. Extracranial metastasis of solitary fibrous tumor has been reported to the lung or mediastinum in six case reports [13,14,15,16,17,18]. To our knowledge, the case in this series is the first known case of a pancreatic metastasis from an intracranial primary.…”

Section: Discussionmentioning

confidence: 68%

Metastases to the Pancreas Diagnosed by Fine-Needle Aspiration

Olson¹,

Wakely²,

Ali³

2013

Acta Cytologica

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Background: Metastatic cancer infrequently involves the pancreas. When the pancreas hosts a metastatic tumor, cytopathological evaluation of fine-needle aspirate material is a crucial part of the diagnostic process. In this study, we show two institutions' experience with cytopathological diagnosis of pancreatic metastasis. Methods: Databases of institutional experience at The Johns Hopkins Hospital and Ohio State University Medical Center were queried for cases of metastatic tumors in the pancreas that underwent fine-needle aspiration. Demographic and pathological features were compiled and the cytomorphology was reviewed. Results: Forty-two cases of tumor metastasis to the pancreas were found. Over the time of this review, 5,495 aspirates were performed, and 43% (2,389/5,495) had malignant cytological findings. Thus, the 42 cases of metastatic disease to the pancreas comprised 0.8% of all pancreas aspirates and 1.8% of the malignant ones. Renal cell carcinoma was the most common metastasis, followed by melanoma and non-small cell lung carcinoma. Among the other tumors in this series, 2 cases each of rare metastases such as the fibrolamellar variant of hepatocellular carcinoma and solitary fibrous tumor were also seen. Conclusion: The pancreas is rarely involved with metastatic disease, but when it is involved the most common tumor is renal cell carcinoma followed by melanoma and non-small cell lung cancer. Clinical history and awareness of the primary pancreatic mimickers are necessary for arriving at the correct diagnosis. As conventional pancreatic adenocarcinoma is uncommon in children and young adults, history of other tumors - even ones that usually follow an indolent course - is essential.

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Section: Discussionmentioning

confidence: 68%

Metastases to the Pancreas Diagnosed by Fine-Needle Aspiration

Olson¹,

Wakely²,

Ali³

2013

Acta Cytologica

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“…Nevertheless, recurrence is known and malignant behavior of SFT involving the central nervous system has been reported in a few cases (5,6,8,11,13,14,30,31,38,39).…”

Section: Discussionmentioning

confidence: 99%

Intramedullary Solitary Fibrous Tumor—A Benign Form of Hemangiopericytoma? Case Report and Review of the Literature

et al. 2015

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“…Other signs of secondary malignant transformation are diminished CD34 expression and positive p53 immunoreactivity [18]. However, Munoz et al [18] believe the histologic findings of SFT are unreliable for predicting behavior, as they presented a case of malignant SFT with multiple metastases that had benign histologic findings (Munoz, 2008). Authors note that the mean follow-up was only 40 months, and thus, the true long-term course of SFT is unknown [1,4].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Malignancy or high risk for recurrence is associated with: hypercellularity, marked nuclear atypia, high mitotic activity, necrosis, high Ki-67 proliferation index and sub-total resection [1,4,18]. Other signs of secondary malignant transformation are diminished CD34 expression and positive p53 immunoreactivity [18]. However, Munoz et al [18] believe the histologic findings of SFT are unreliable for predicting behavior, as they presented a case of malignant SFT with multiple metastases that had benign histologic findings (Munoz, 2008).…”

Section: Discussionmentioning

confidence: 99%

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