A Rare Case of Nasal Septal Perforation Due to Purpureocillium lilacinum: Case Report and Review

Shivaprasad, Aparna; Ravi, G. C.; Shivapriya,; RAMA, .

doi:10.1007/s12070-012-0570-1

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…This study made use of many different previously analyzed infant datasets. These datasets have previously published descriptions of the study design, patient selection, and sample collection, and are referred to as NIH1 [51, 52], NIH2 [19], NIH3 [53], NIH4 [54], Sloan2 [19], and SP_CRL [55]. Infants were chosen for inclusion in this study irrespective of fungal disease state.…”

Section: Methodsmentioning

confidence: 99%

“…Post-sequencing bcl files were converted to demultiplexed fastq files per the original sample count with Illumina’s bcl2fastq v2.19 software. New metagenomic data was processed in the same manner as in the prior studies, and as described previously [54].…”

Section: Methodsmentioning

confidence: 99%

“…Bacterial phyla-level abundance was determined by summing the relative abundance of all bacterial genomes present in a sample. Bacterial genomes for previously sequenced samples are available in a previous publication [54], and bacterial genomes for newly sequenced genomes were binned using the same methods. Metadata was filtered such that between 20 and 80% of values were non-zero in both samples containing eukaryotes and samples not containing eukaryotes.…”

Section: Methodsmentioning

confidence: 99%

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Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms

et al. 2019

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Background Fungal infections are a significant cause of mortality and morbidity in hospitalized preterm infants, yet little is known about eukaryotic colonization of infants and of the neonatal intensive care unit as a possible source of colonizing strains. This is partly because microbiome studies often utilize bacterial 16S rRNA marker gene sequencing, a technique that is blind to eukaryotic organisms. Knowledge gaps exist regarding the phylogeny and microdiversity of eukaryotes that colonize hospitalized infants, as well as potential reservoirs of eukaryotes in the hospital room built environment. Results Genome-resolved analysis of 1174 time-series fecal metagenomes from 161 premature infants revealed fungal colonization of 10 infants. Relative abundance levels reached as high as 97% and were significantly higher in the first weeks of life ( p = 0.004). When fungal colonization occurred, multiple species were present more often than expected by random chance ( p = 0.008). Twenty-four metagenomic samples were analyzed from hospital rooms of six different infants. Compared to floor and surface samples, hospital sinks hosted diverse and highly variable communities containing genomically novel species, including from Diptera (fly) and Rhabditida (worm) for which genomes were assembled. With the exception of Diptera and two other organisms, zygosity of the newly assembled diploid eukaryote genomes was low. Interestingly, Malassezia and Candida species were present in both room and infant gut samples. Conclusions Increased levels of fungal co-colonization may reflect synergistic interactions or differences in infant susceptibility to fungal colonization. Discovery of eukaryotic organisms that have not been sequenced previously highlights the benefit of genome-resolved analyses, and low zygosity of assembled genomes could reflect inbreeding or strong selection imposed by room conditions. Electronic supplementary material The online version of this article (10.1186/s40168-019-0638-1) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms

et al. 2019

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“…nov. is a filamentous, hyaline, anamorphic fungus ( Luangsa-Ard et al, 2011 ) considered an emerging pathogen in humans, especially immunosuppressed. However, the number of immunocompetent hosts infected by this fungus increased in recent years ( Saghrouni et al, 2013 ; Shivaprasad et al, 2013 ; Todokoro et al, 2014 ; Borba and Brito, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Experimental Hyalohyphomycosis by Purpureocillium lilacinum: Outcome of the Infection in C57BL/6 Murine Models

et al. 2017

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Purpureocillium lilacinum is a filamentous, hyaline fungus considered an emerging pathogen in humans. The aim of our study was to evaluate the outcome of hyalohyphomycosis in C57BL/6 murine models inoculated with two clinical P. lilacinum isolates (S1 and S2). Each isolate was inoculated in mice randomly distributed in immunocompetent (CPT) and immunosuppressed (SPS) groups. Mice were evaluated at day 7, 21, and 45 after inoculation for histopathological analysis, recovery of fungal cells, and immunological studies. Histological analysis showed scarce conidia-like structures in lung tissue from CPT mice and a lot of fungal cells in SPS mice inoculated with S2 compared to mice inoculated with S1. The maximum recovery of fungal cells was seen in CPT mice inoculated with both isolates at day 7, but with mean significantly higher in those inoculated with S2 isolate. Phenotypical characterization of T cells showed TCD8+ lymphocytes predominance over TCD4+ in immunosuppressed mice infected and control groups. We also observed higher percentages of the central and effector memory/effector phenotype in CPT mice infected with S2 strain, especially in TCD8+ in the initial period of infection. Regulatory T cells showed higher percentages in immunosuppressed, predominantly after the acute phase. Our results showed that the P. lilacinum is a fungus capable to cause damages in competent and immunosuppressed experimental hosts. Furthermore, S2 isolate seems to cause more damage to the experimental host and it was possible to identify different cellular subsets involved in the mice immune response.

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“…Описан случай образования ППН на фоне обсе мененности полости носа грибом Purpureocillium lilacinum у иммунокомпетентного 35летнего муж чины [33].…”

Section: Introductionunclassified

Nasal septal perforations: Etiology, pathogenesis, clinical manifestation and treatment (A review of literature)

Чекалдина¹

2016

Ross. rinol.

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Перфорация перегородки носа (ППН) -это за болевание, при котором нарушается целостность слизистой оболочки и хряща перегородки носа (ПН) [1]. Распространенность ППН в популяции, по не которым данным, составляет 0,9% [2].Основной причиной ППН (по данным разных авторов, около 60%) остаются ятрогенные факторы: предшествующая операция на ПН, электрокоагуля ция или радиоволновое прижигание сосудов на ПН при носовых кровотечениях, особенно, если они выполняются симметрично с обеих сторон, уста новка интраназальных стентов, длительная тампо нада носа, неаккуратно выполненный туалет носа после операции, когда наконечником отсоса трав мируется слизистая оболочка [3][4][5][6][7][8][9][10][11][12][13].К ятрогенным факторам относятся также по грешности при лечении [1,4,[11][12][13]. Одним из важных причинных факторов ППН является травма doi: 10.17116/rosrino201624124-27 Перфорации перегородки носа: этиология, патогенез, клиника и лечение (обзор литературы) Е.В. ЧЕКАЛДИНА ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва, Россия В обзоре представлены данные литературы о распространенности перфораций перегородки носа (ППН), описаны этиологические факторы, ведущие к их образованию. Рассмотрены ятрогенные (операции на перегородке носа, репозиции костей носа) и профессиональные факторы риска, описаны причины образования ППН на фоне злоупотребления различными интраназальными веществами, вследствие системных воспалительных или инфекционных заболеваний, новообразований, а также возникающие после проведения системной химиотерапии. В зависимости от размеров и расположения ППН описаны симптомы заболевания: свист при дыхании, сухость, носовые кровотечения, деформация наружного носа; рассмотрены варианты бессимптомных перфораций. Описано консервативное лечение при больших размерах ППН, которое, по сути, является паллиативным при данной патологии. Представлены варианты хирургического лечения, которые направлены не на закрытие перфорации, но могут улучшить носовое дыхание и уменьшить проявление заболевания. Описана методика использования «назальных пуговиц» как альтернатива хирургическому лечению при наличии противопоказаний к пластическому закрытию ППН. The review gives the data available in the literature on the prevalence of nasal septal perforations (NSP) and describes the etiological factors leading to their development. It considers iatrogenic (nasal septal surgery, nasal bone repositions) and occupational risk factors and describes the causes of NSP in the abuse of different intranasal substances, because of systemic inflammatory or infectious diseases, neoplasms, as well as those occurring after systemic chemotherapy. The disease symptoms, such as wheezing, dryness, nasal hemorrhage, external nasal deformity, are described according to the sizes and position of NSP; the types of asymptomatic perforations are considered. The paper depicts the medical treatment for large NSP, which is per palliative for this pathology. It presents surgical treatments that are aimed at...

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A Rare Case of Nasal Septal Perforation Due to Purpureocillium lilacinum: Case Report and Review

Cited by 10 publications

References 18 publications

Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms

Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms

Experimental Hyalohyphomycosis by Purpureocillium lilacinum: Outcome of the Infection in C57BL/6 Murine Models

Nasal septal perforations: Etiology, pathogenesis, clinical manifestation and treatment (A review of literature)

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