A rare case of olfactory groove schwannoma

Figueiredo, Eberval Gadelha; Gomes, Marcos da Silva; Soga, Youji; Amorim, Robson Luís Oliveira de; Rosemberg, Sérgio; Teixeira, Manoel Jacobsen

doi:10.1590/s0004-282x2009000300034

Cited by 12 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The developmental theories suggest either transformation of mesenchymal pial cell into ectodermal Schwann cells or migration of the neural crest cells within the central nervous system (10). Also, dural branches of peripheral nerves which pass through the anterior cranial fossa may be nerves of origin for these tumors.…”

Section: █ Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ancient olfactory schwannoma - case report and literature review

Micovic¹,

Živković²,

Zivanovic³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

ABSTRACTsignal intensity on T2-weighted images. The signal intensity on T2-weighted images may be either homogeneously hyperintense or it can show a characteristic high signal intensity in the periphery and low signal intensity in the central region of the lesion. This MR imaging finding corresponds with pathologic findings to fibrous tissue (with high collagen content) centrally and more myxoid tissue peripherally (20).Histopathologically, it consists of compact hypercellular Antoni A areas and myxoid hypocellular Antoni B areas. Cells are narrow, elongated and wavy with tapered ends interspersed with collagen fibers -spindle cells. Nuclear palisading around fibrillary processes (Verocay bodies) are often seen in cellular areas. Large irregularly spaced vessels, usually with thickened hyalinized walls and thrombi, are most prominent in Antoni B areas. Tumor cells have ill-defined cytoplasm, dense chromatin. It often displays degenerative nuclear atypia, but █ INTRODUCTION I ntracranial schwannomas are benign tumors that arise from Schwann cells. Since it is well known that optic and olfactory nerves do not have a Schwann cell sheath, schwannoma should not develop from these nerves (17).Schwannomas account for 8 -10 % of all intracranial tumors and occur mostly in patients between 20 and 50 years of age. Patients affected by schwannomas may be asymptomatic or present with various symptoms depending on the location, size and nerve of origin, and may include motor and sensory dysfunction, intracranial hypertension, headache and seizures (20).These tumors present on Magnetic Resonance Imaging (MRI) as well-circumscribed, encapsulated masses, low-to intermediate signal intensity on T1-weighted images and high Intracranial schwannomas are benign tumors that arise from Schwann cells. Since it is well known that optic and olfactory nerves do not have a Schwann cell sheath, schwannoma should not develop from these nerves.We report a very unusual case of a 73-year-old female who presented with generalized seizures and had radiological features of an intracranial aneurysm. Additional imaging showed an extracerebral mass 2.5 x 2.0 cm in size, which most likely corresponded to a meningioma. It was resected in total. Subsequent histological analysis revealed that the tumor was in fact ancient schwannoma WHO grade I.Only about 41 case of olfactory schwannoma have been reported in the literature. Olfactory groove schwannomas are extremely rare tumors, occurring less frequently than any other intracranial nerve schwannoma. As in this case, the schwannoma should be included in the differential diagnosis of the anterior cranial fossa tumor. Further research on the pathogenesis and the origin of olfactory groove schwannoma is needed.

show abstract

Section: █ Discussionmentioning

confidence: 99%

“…Different course of treatment for schwannomas include surgical excision, observation and radiotherapy (10).…”

Section: Introductionmentioning

confidence: 99%

Ancient olfactory schwannoma - case report and literature review

Micovic¹,

Živković²,

Zivanovic³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Schwann cells cover unmyelinated axons of the nerve fibers up to 0.5 mm before the olfactory bulb, and OECs, likewise, until two external layers of the olfactory bulb, to facilitate axonal growth. [11][12][13] On MRI exams, these lesions appear as a well-circumscribed and encapsulated mass, expressing low to intermediate signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The hyperintensity on T2-weighted images may either be homogeneous or show a target sign with high signal intensity in the periphery of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Olfactory Groove Schwannoma—A Case Report and Literature Review

et al. 2018

View full text Add to dashboard Cite

Olfactory groove schwannomas (OGSs) are rare benign tumors of the anterior skull base region. Considering the lack of Schwann cells in the optic and olfactory nerves, their origin remains enigmatic. Despite the precursor cell, total resection of the lesion is curative, as long as the histopathological features of the tumor are compatible with schwannoma. We report the case of a 32-year-old woman, addicted to crack, who was brought to the hospital presenting with cognitive dysfunction after being physically assaulted, whose neuroimaging revealed a large extra-axial mass in the subfrontal sagittal region. The presentation, immunohistochemical markers and histogenesis are discussed in the present study, along with a literature review.

show abstract

“…The most common place for intracranial schwannomas is the posterior fossa of the brain. Intracranial schwannomas account for 6-8% of all intracranial tumors [ 2 ]. Most commonly, schwannomas arise from the 8th cranial nerve, and less frequently from the 5th, 9th, 10th, and 7th cranial nerves.…”

Section: Introductionmentioning

confidence: 99%

“…Most commonly, schwannomas arise from the 8th cranial nerve, and less frequently from the 5th, 9th, 10th, and 7th cranial nerves. The occurrence of a schwannoma not related to the cranial nerves is extremely rare [ 2 ]. Because the olfactory and optic nerves lack a Schwann cell layer, these are not prone to develop into a schwannoma [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Olfactory Groove Schwannoma Attached to the Cribriform Plate: A Case Report

Kim

Yoon

Kie

et al. 2015

Brain Tumor Res Treat

View full text Add to dashboard Cite

The olfactory groove schwannoma is a quite rare tumor. We report a case of a 49-year-old woman with an olfactory groove schwannoma attached to the cribriform plate without olfactory dysfunction. She had no specific neurological symptoms other than a headache, and resection of the tumor showed it to be a schwannoma. About 19 months after the operation, a follow-up MRI showed no evidence of tumor recurrence. Surgical resection through subfrontal approach could be one of the curative modality in managing an olfactory groove schwannoma. An olfactory groove schwannoma should be considered in the differential diagnosis of anterior skull base tumors.

show abstract

A rare case of olfactory groove schwannoma

Cited by 12 publications

References 7 publications

Ancient olfactory schwannoma - case report and literature review

Ancient olfactory schwannoma - case report and literature review

Olfactory Groove Schwannoma—A Case Report and Literature Review

The Olfactory Groove Schwannoma Attached to the Cribriform Plate: A Case Report

Contact Info

Product

Resources

About