2008
DOI: 10.1007/s11102-008-0099-1
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A rare case of paraganglioma of the sella with bone metastases

Abstract: Sellar paragangliomas are very rare lesions with only 11 previous cases described in the literature. We present a further case of sellar paraganglioma. The patient is a 17-year-old man who developed headache, visual blurring, and diplopia. MRI showed a sellar lesion. Trans-nasal trans-sphenoid biopsy showed features of paraganglioma. He was treated by Stereotactic radiotherapy. Four months after treatment he developed bone metastases which was palliated by radiation, zoledronic acid, and chemotherapy. This is … Show more

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Cited by 16 publications
(7 citation statements)
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“…It is recommended that a total of 45 Gy be given for paraganglioma lesions involving the spine [36]. There is little evidence regarding chemotherapy for paragangliomas, so the effect of chemotherapy to treat malignant paraganglioma is still controversial [37]. Current studies mainly focus on CVD (cyclophosphamide, vincristine, Dacarbazine) chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…It is recommended that a total of 45 Gy be given for paraganglioma lesions involving the spine [36]. There is little evidence regarding chemotherapy for paragangliomas, so the effect of chemotherapy to treat malignant paraganglioma is still controversial [37]. Current studies mainly focus on CVD (cyclophosphamide, vincristine, Dacarbazine) chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Paragangliomas are rare neuroendocrine tumors that might affect several different regions including head and neck, adrenal, filum terminale and even central nervous system. Paragangliomas affecting the sellar region are extremely rare with a few documented cases so far .…”
Section: Discussionmentioning
confidence: 99%
“…Paragangliomas are rare neuroendocrine tumors that might affect several different regions including head and neck, adrenal, filum terminale and even central nervous system. Paragangliomas affecting the sellar region are extremely rare with a few documented cases so far (1,2,3,4,5,6). The development of paragangliomas in unusual regions such as the sella turcica might be due to the presence of remnants of paraganglionic tissue or due to abnormal migration; it is important to notice that no paraganglionic cells are detected in pituitary or adjacent tissue in adults.…”
Section: Discussionmentioning
confidence: 99%
“…Given the normal distribution of paraganglia associated with components of the autonomous nervous system, it should be no surprise that paragangliomas can occur in the gallbladder [ 11 , 12 ], and the liver [ 8 , 13 , 14 ], where they are likely to arise from small abdominal vagus nerve branches. Paraganglia are present and can give rise to paragangliomas in various sites including the orbit, mandible, paranasal sinuses and sellar region [ 8 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], adjacent to or within the thyroid gland [ 8 , 24 , 25 , 26 , 27 , 28 , 29 ], in the parathyroid [ 30 ], in the mediastinum [ 8 , 31 , 32 , 33 ], within the lungs and heart [ 8 , 34 , 35 , 36 , 37 , 38 ], gut [ 8 ], and pancreas [ 8 , 39 , 40 ] and in the mesentery [ 8 , 41 , 42 ].…”
Section: Distribution and Localization Of Paragangliomasmentioning
confidence: 99%