A Rare Case of Porocarcinoma and Trichoblastoma Arising in a Nevus Sebaceus of Jadassohn

Abstract

Nevus sebaceus of Jadassohn, or “organoid nevus,” is a common, benign hamartoma of the skin consisting of epithelial and adnexal components. Its natural history and association with neoplastic growths is well documented. The majority of concomitant neoplasms are benign—trichoblastoma and syringocystadenoma papilliferum are most frequently discovered—but malignant tumors have been described. We present the case of a 58-year-old male with a congenital nevus sebaceus of Jadassohn on his left parietal scalp that had been enlarging, changing color, and bleeding over the prior year. Clinical exam and histology disclosed the presence of a trichoblastoma and porocarcinoma arising within the nevus sebaceus. Porocarcinoma is a rare, intermediately aggressive, malignant eccrine gland tumor that is frequently metastasized at presentation. Otolaryngology performed wide local resection with sentinel lymph node biopsy. This case highlights the diversity of tumors associated with nevus sebaceus of Jadassohn, potential for malignant expansion, and necessity for close monitoring and maintaining a low threshold for biopsy in evolving lesions.

Porocarcinoma of the Left Arm: A Report of a Rare Skin Cancer Case and Literature Review

“…To date, only 15 cases occurring on the arms (including the current case) have been documented in the literature [6][7][8][9][10][11][12][13][14][15][16]. Clinically, PC presents as a slow-growing, red, dome-shaped skin nodule with a shiny surface or as a wart-like plaque, papule, or polyp that is sometimes painful and ulcerative.…”

“…Mortality is high, reaching 80% in distant diseases and 65%-67% when lymph nodes are involved. Given its rare occurrence, most of the literature has reported single clinical cases and a few case series, and there are currently no uniform international guidelines for these patients [6][7][8][9][10][11][12][13][14][15][16].…”

“…Recent literature has reported that PC most commonly arises on the lower limbs (33%), head and neck (32%), trunk (14.7%), genitalia/buttocks (11.2%), and upper limbs (7.4%). The location on the arms represents only 4.8% of PC common sites (only 14 cases have been registered at the moment) [6][7][8][9][10][11][12][13][14][15][16].…”

Porocarcinoma of the left arm: A report of a rare skin cancer case and literature review

“…To date, only 15 cases occurring on the arms (including the current case) have been documented in the literature. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 Clinically, PC presents as a slow‐growing, red, dome‐shaped skin nodule with a shiny surface or as a wart‐like plaque, papule, or polyp that is sometimes painful and ulcerative. The lesion size can range from <1 cm to up to 10 cm.…”

“…The location on the arms represents only 4.8% of PC common sites (only 14 cases have been registered at the moment). 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 …”