A rare case of Pseudomonas aeruginosa bacteremia in a newborn with 58 perforations in the small intestine

Xu, Yuanyuan; Jin, Di; Ye, Huan; Liang, Youfeng

doi:10.1186/s12887-020-02466-2

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Overall, these results further illustrate the potential role of biotransformation with CYP enzymes in the production of natural product derivatives. Given the role of P. aeruginosa as a human pathogen, which can cause infections in the liver, small intestine, and urinary tract, − and the importance of alkylquinolones in modulating pathogenicity, the oxidative degradation of these compounds by CYP4F11 could also have implications for human health.…”

Section: Resultsmentioning

confidence: 99%

Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11

Shi,

Li,

Wolf

et al. 2023

J. Nat. Prod.

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2-Alkylquinolones are a class of microbial natural products primarily produced in the Pseudomonas and Burkholderia genera that play a key role in modulating quorum sensing. Bacterial alkylquinolones were synthesized and then subjected to oxidative biotransformation using human cytochrome P450 enzyme CYP4F11, heterologously expressed in the fission yeast Schizosaccharomyces pombe. This yielded a range of hydroxylated and carboxylic acid derivatives which had undergone ω-oxidation of the 2-alkyl chain, the structures of which were determined by analysis of NMR and MS data. Oxidation efficiency depended on chain length, with a chain length of eight or nine carbon atoms proving optimal for high yields. Homology modeling suggested that Glu233 was relevant for binding, due to the formation of a hydrogen bond from the quinolone nitrogen to Glu233, and in this position only the longer alkyl chains could come close enough to the heme moiety for effective oxidation. In addition to the direct oxidation products, a number of esters were also isolated, which was attributed to the action of endogenous yeast enzymes on the newly formed ω-hydroxy-alkylquinolones. ω-Oxidation of the alkyl chain significantly reduced the antimicrobial and antibiofilm activity of the quinolones.

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Section: Resultsmentioning

confidence: 99%

Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11

Shi,

Li,

Wolf

et al. 2023

J. Nat. Prod.

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“…It has been suggested that Pseudomonas spp. can cause a variety of infectious diseases in newborns, including septicemia, meningitis, NEC, and intestinal injury [34] , [35] , [36] , [37] , [38] . Taken together, our results suggest that increasing abundance of Pseudomonas spp.…”

Section: Discussionmentioning

confidence: 99%

Prolonged premature rupture of membranes with increased risk of infection is associated with gut accumulation of Pseudomonas from the environment

Xiang,

Yan,

Shi

et al. 2024

Computational and Structural Biotechnology Journal

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“…The typical patient presenting with nosocomial P. aeruginosainfection is mechanically ventilated, has slowly progressive lung infiltrates, and has been colonized for days 6 . Community-acquired P. aeruginosa infections are rare but have an acute onset, rapid progression, and lead to the development of short-term shock 7,8 . The patient in our study diagnosed severe community-acquired pneumonia (CAP) due to P. aeruginosa and also progressed to septic shock quickly.…”

Section: Discussionmentioning

confidence: 99%

Late diagnosis of X-linked hyper-IgM syndrome presenting as community-acquired pseudomonas aeruginosa pneumonia-related septic shock

Lin

Chen

Xie

et al. 2022

Preprint

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Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative aerobic bacterium, which is rarely seen in community-acquired infection. Attention should be paid to its high mortality and invasive progress. X-linked hyper-IgM syndrome (XHIGM; HIGM1; OMIM:308230) is one type of primary immunodeficiency disease (PIDs), characterized by markedly decreased serum IgG, IgA, and IgE levels and normal or elevated serum IgM levels. We report a patient who developed a particularly severe community-acquired P. aeruginosa pneumonia-related septic shock, and a delayed diagnosis of X-linked hyper IgM syndrome was made by genome sequencing. Fatal community-acquired P. aeruginosa infections in children, including previously healthy children, should be considered to search for underlying PIDs by exome/genome sequencing.

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A rare case of Pseudomonas aeruginosa bacteremia in a newborn with 58 perforations in the small intestine

Cited by 5 publications

References 8 publications

Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11

Expected and Unexpected Products from the Biochemical Oxidation of Bacterial Alkylquinolones with CYP4F11

Prolonged premature rupture of membranes with increased risk of infection is associated with gut accumulation of Pseudomonas from the environment

Late diagnosis of X-linked hyper-IgM syndrome presenting as community-acquired pseudomonas aeruginosa pneumonia-related septic shock

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