A rare case of purpuric rash caused by Saprochaete clavata in a pediatric patient with acute leukemia

Abstract

We present a 13‐year‐old boy who developed invasive infection with Saprochaete clavata after induction chemotherapy for B‐cell acute lymphoblastic leukemia, complicated by fungemia, septic shock and acute renal, and liver failure. He developed purpuric papulonodules over bilateral upper and lower limbs, which also grew S clavata on fungal culture.

Disseminated fungal disease caused by Magnusiomyces clavatus in a pediatric cancer patient: Case report and review of the literature

“…Fungal isolates were identified almost exclusively from blood cultures with CSF and skin biopsy samples also documented. 18,22 As with our case, the most commonly used antifungal regimen was voriconazole, amphotericin-B, and flucytosine. Mortality rates, when noted, are more favorable with survival in 80% of cases.…”

“…Our literature search yielded 10 cases from 2007 to 2022. 6,[14][15][16][17][18][19][20][21][22][23] Acute leukemias were the most common underlying diagnoses and all patients were immunocompromised during infection. Disseminated spread occurred in all but two cases.…”

Invasive fungal disease presenting as septic shock in immunocompromised pediatric and adult patients: summary of reported cases

“…Literature data describing etiology, age and outcome is very limited. The available pediatric data includes 22 patients, most of them with an underlying non-hematological disease (Table I) [12][13][14][15][16][17][18][19][20][21][22]. Only 6/22 (27.3%) are reported to have survived this infection, including 2/4 with acute leukemia.…”

Disseminated Fungal Disease Caused by Magnusiomyces clavatus in a Pediatric Cancer Patient: First Case Report in North America and Review of the Literature

“…Disseminated spread occurred in all but two cases. Fungal isolates were identified almost exclusively from blood cultures with CSF and skin biopsy samples also documented 18,22 . As with our case, the most commonly used antifungal regimen was voriconazole, amphotericin-B, and flucytosine.…”