A rare case of recurrent secretory meningioma with malignant transformation

Abstract

A 72-year-old woman previously operated for a sphenoid-ridge meningioma, now presented with double vision. Histology showed a secretory meningioma with an epithelial-appearing, malignant component. Malignant transformation in a secretory meningioma is not known. This is the first report of such an occurrence.

Immunohistochemical study of the extracellular matrix proteins laminin, fibronectin and type IV collagen in secretory meningiomas

“…[6][7][8] Recently, reports of a case of anaplastic SM and a case of recurrent SM with malignant transformation have been published. 30,31 With all of the above considered, total resection is mandatory, whenever possible, with resection of a wide margin of dura around the site of tumor attachment. Careful clinical observation of patients with meticulous neuroradiological follow-up is also recommended.…”