A rare case of renal collision tumour of oncocytoma and sarcomatoid renal cell carcinoma

Abstract

Level of evidence: 4

Renal Oncocytoma and Pelvic Urothelial Carcinoma in a Nephrectomy Specimen of a 72-Year-Old Patient

“…This term is often used interchangeably with composite tumors; however, collision tumors lack histologic intermingling. Possible hypotheses for this phenomenon include a coincidental occurrence of two tumors, a common carcinogenic stimulus that alters the microenvironment in the vicinity of both the tumors, and finally, the first tumor altering the cellular environment in such a manner as to facilitate the development of a second tumor [9] Renal oncocytomas are benign renal neoplasms that have been known to coexist with numerous other renal malignancies [6,10,11]. They have a common cell of origin with chromophobe renal cell carcinoma (intercalated cells of the collecting duct).…”

“…Renal oncocytomas are benign renal neoplasms that have been known to coexist with numerous other renal malignancies [ 6 , 10 , 11 ]. They have a common cell of origin with chromophobe renal cell carcinoma (intercalated cells of the collecting duct).…”

“…On extensive review of the literature, we could find only one reported case of synchronous renal oncocytoma and pelvic urothelial carcinoma [ 5 ], although it has been reported with other malignancies also [ 6 , 7 ].…”

Letter to the Editor re: A rare case of renal collision tumour of oncocytoma and sarcomatoid renal cell carcinoma, Chang et al.

“…I read with great interest the recent case report by Chang et al: 'A rare case of renal collision tumour of oncocytoma and sarcomatoid renal cell carcinoma'. 1 A case is presented of a 77-year-old woman who presented with night sweats, weight loss and systemic symptoms and a palpable flank mass. A subsequent computed tomography scan revealed a 13 cm renal mass with adenopathy and caval extension necessitating radical nephrectomy, lymphadenectomy and caval exploration.…”

“…12 Undoubtedly, as the incidental detection of renal masses increases due to radiological intervention the rate of oncocytoma detection will alter in tandem. Given the predilection of larger oncocytomas (>pT1) to harbour incidental tumours, careful sectioning and histological analysis is necessary to detect incidental tumours such as that described by Chang et al 1,9…”