A Rare Case of Schwann Cell Hamartoma in the Duodenum

Oguntuyo, Kasopefoluwa Y.; Donnangelo, Lauren L.; Zhu, Guangjing; Ward, Stephen G.; Bhattacharaya, Abhik

doi:10.14309/crj.0000000000000894

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Histopathology confirmed the same histopathological features as those in colonic MSCH. Additionally, Oguntuyo et al [ 14 ] reported a case of MSCH in the duodenum, and Ismael et al reported another case of MSCH in the gallbladder in a patient who presented with abdominal pain, common bile duct stones, gallbladder thickening, marked biliary dilatation, and pancreatic ductal dilatation [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Schwann Cell Hamartoma in Colon

Salam¹,

Abosheaishaa²,

Rasool³

et al. 2023

Cureus

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Schwann cell tumors are benign tumors originating from Schwann cells of the peripheral nervous system and are extremely rare in the gastrointestinal system. They usually originate in the colon or rectum but can also occur in the esophagus and small intestine. Their occurrence is rare in GI tract and mainly in the sigmoid colon. Schwann cell tumors have no association with any familial cancer syndromes. We present a 65-year-old female patient who underwent routine colon cancer screening. In addition to open mouth diverticulosis, she was found to have a 3 mm polyp, which was diagnosed as a Schwann cell hamartoma after a biopsy. This study aimed to present this rarely reported case in the literature as an example of a tumor that should be included in the differential diagnosis when considering submucosal colonic lesions. Though the reported reoccurrence rate is low, this case highlights the lack of published guidelines regarding appropriate follow-up surveillance periods.

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Section: Discussionmentioning

confidence: 99%

An Unusual Case of Schwann Cell Hamartoma in Colon

Salam¹,

Abosheaishaa²,

Rasool³

et al. 2023

Cureus

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“…These polyps are primarily found in the colon but can also appear in different parts of the gastrointestinal system, such as the gallbladder [7] . Since their discovery in 2009, several cases of mucosal Schwann cell hamartomas have been reported, and they are all histologically similar [8][9][10][11][12][13] . These polyps are not associated with inherited syndrome and pose no risk of malignancy.…”

Section: D a Bmentioning

confidence: 99%

Mucosal Schwann cell hamartoma on screening colonoscopy: an unusual finding

Barjas,

Yahia,

Abuodeh

et al. 2024

European Journal of Case Reports in Internal Medicine

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Schwann cells are found in the peripheral nervous system and can sometimes appear as benign hamartoma lesions in various parts of the body. Although rare in the gastrointestinal (GI) tract, they have been observed in the colon. Recently, mucosal Schwann cell hamartomas of the GI tract have been studied, and it was discovered that they had yet to be investigated up to 2009. In this context, we present the case of a 60-year-old man who was found to have lesions in the transverse colon during a routine colonoscopy. No further investigations were conducted since these lesions have not been associated with any risk of malignancy transformation and have not been linked to any inherited syndromes.

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“…MSCHs are distinctively positive for S-100 protein, setting them apart from other gastrointestinal neoplasms, such as gastrointestinal stromal tumors (negative for KIT), leiomyomas (negative for smooth muscle actin), neurofibromas (negative for CD34), and perineuromas (negative for epithelial membrane antigen or claudin-1). The term MSCH was introduced into the medical literature in 2009, and these tumors have been identified in various locations within the gastrointestinal tract, including the gastroesophageal junction, gastric antrum, gallbladder, and cecum [ 1 , 3 ]. Schwannoma is usually asymptomatic and is an incidental finding on surveillance colonoscopies [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report With a Literature Review

Altaf,

Javed,

Ghazanfar

et al. 2024

Cureus

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Mucosal Schwann cell hamartomas (MSCHs) are non-common noncancerous growths derived from Schwann cells in the peripheral nervous system, often found unexpectedly during routine colonoscopy examinations. These growths primarily occur in the colon, although they can also appear in the esophagus and are not linked to familial cancer syndromes. Diagnosis relies on specific histological characteristics and staining patterns. It is essential to distinguish MSCHs accurately since their appearance can closely resemble that of malignant tumors. Characteristically, these hamartomas test positive for S-100 protein but do not exhibit markers typical of other gastrointestinal growths, such as gastrointestinal stromal tumors (negative for KIT), leiomyomas (negative for smooth muscle actin), neurofibromas (negative for CD34), and perineuromas (negative for epithelial membrane antigen or claudin-1). This report discusses the case of a 48-year-old woman who was diagnosed with MSCH during a screening colonoscopy.

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A Rare Case of Schwann Cell Hamartoma in the Duodenum

Cited by 3 publications

References 13 publications

An Unusual Case of Schwann Cell Hamartoma in Colon

An Unusual Case of Schwann Cell Hamartoma in Colon

Mucosal Schwann cell hamartoma on screening colonoscopy: an unusual finding

Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report With a Literature Review

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