A Rare Case of Solitary Plasmacytoma Mimicking a Primary Lung Tumor

Goździuk, K; Kedra, M; Rybojad, Paweł; Sagan, Dariusz

doi:10.1016/j.athoracsur.2008.11.066

Cited by 18 publications

(5 citation statements)

References 6 publications

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“…[9] Extramedullary existence of plasmacytoma is not common and the incidence of thoracic cases is low, especially in patients presenting with pulmonary plasmacytoma and malign pleural efusion to simulate a pleural mesothelioma or lung cancer. [6,10] We report here a unique presentation of PCM to include monoclonal components and lung plasmacytoma as initially mistaken for metastatic lung cancer.…”

Section: Discussionmentioning

confidence: 94%

Multiple myeloma mimicking metastatic lung cancer

Furuncuoglu¹,

Cirak²,

Türk³

et al. 2015

TJ Oncol

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Multiple myeloma is a hematological malignancy characterized by a clonal proliferation of plasma cells in the bone marrow. Extramedullary dissemination of multiple myeloma is uncommon. Only in rare cases, the malignant plasma cells of multiple myeloma had infiltrated the lung parenchyma. In this case report, we presented a case of multiple myeloma with lung plasmacytoma, in a 42-year-old patient, hospitalized for pain and infiltrative mass in the right lung. The results of his initial evaluation with computed tomography and positron emission tomograpy scanning, resembled lung tumor with bone metastasis. Surprisingly, biopsies from lung tumor and bone metastasis, revealed malignant plasma cells. We found M spike in protein electrophoresis and lambda monoclonal band in immune electrophoresis. A bone marrow biopsy evaluation was done and justified multiple myeloma diagnosis before hematology referral. Multiple myeloma diagnosis at the age of 42 is quite rare.Keywords: Cancer; lung; metastasis; myeloma.Multipl miyelom kemik iliğinde plasma hücrelerinin klonal proliferasyonu ile karekterize hematolojik malign bir hastalıktır. Multipl miyelomda ekstramedüller yayılım sık değildir. Çok nadir olgularda multipl miyelom nedenli plazma hücrele-ri akciğer parankimini infiltre eder. Bu yazıda, sağ akciğerde infiltratif kitle ve ağrı nedeniyle hastaneye yatırılan, akciğer plasmasitomlu multipl miyelomu olan 42 yaşında bir hasta sunuldu. Bilgisayarlı tomografi ve pozitron emisyon tomografisi ile yapılan ilk değerlendirmede kemik metastası olan akciğer tümörüne benzetildi. Akciğerdeki tümörden ve kemikteki metastastan yapılan biyopside sürpriz olarak malign plazma hücreleri görüldü. Protein elektroforezinde M spike ve immün elektroforezde monoklonal lamda bandı bulundu. Kemik iliği biyopsisi yapıldı ve multipl miyelom tanısı konarak hematolojiye refere edildi. Multipl miyelom 42 yaşında nadir görülür.

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Section: Discussionmentioning

confidence: 94%

Multiple myeloma mimicking metastatic lung cancer

Furuncuoglu¹,

Cirak²,

Türk³

et al. 2015

TJ Oncol

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“…PPP is extremely rare, whereas, pulmonary involvement with multiple myeloma is more common. [1][2][3] Although EMP can arise throughout the body, almost 90% of cases occur in the head and neck, where they typically exhibit a close relationship to mucus membranes.…”

Section: Discussionmentioning

confidence: 99%

A Case of Primary Solitary Pulmonary Plasmacytoma

Ujiie

Okada

Nakajima

et al. 2012

ATCS

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Most solitary extramedullary plasmacytomas are plasma cell tumors that tend to develop in mucosa-associated lymphoid tissues including the upper respiratory tract. We present a 43-year-old patient who was diagnosed with a solitary plasmacytoma in the lung. Primary plasmacytoma of the lung is exceedingly rare, and the treatment is surgical excision. This malignancy advances to multiple myeloma in a minority of patients. Multiple myeloma is a plasma cell malignancy that typically presents in the bone marrow.

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“…In a literature survey comprising 869 patients with EMPs, only 15 cases showed an affection of the lung [2]. In addition, less than 50 cases of PPP have been published so far [6,7]. An analysis of the early literature is difficult due to the different diagnostic criteria for EMP until 2004, when a consensus definition was established [8].…”

Section: Discussionmentioning

confidence: 99%