A Rare Case of Stage IV Basaloid Squamous Cell Cancer with Intrapulmonary and Brain Metastases

Grandhe, Sundeep; Bajaj, Tushar; Duong, Hanh; Ratnayake, Saman

doi:10.12659/ajcr.915073

Cited by 3 publications

(1 citation statement)

References 13 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alem and Alnoury reported a 67% recurrence rate for sinonasal SpCC [8]. Other authors have reported a mortality rate of 42% in 2.5 years for SpCC in other locations in the body, which reflects the significant aggressive behavior of this tumor [10,11]. No definite conclusion for prognosis of SpCC of head and neck was noted in a case series analyzed and reported by Iqbal et al However, they concluded that the tongue SpCC are more aggressive regardless the treatment modality used [9].…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

Challenging differential diagnosis Background:Carcinosarcoma of the sinonasal tract is an extremely rare malignant neoplasm; it is often designated as carcinoma with spindle cell or sarcomatoid features. We report a case of carcinosarcoma arising in a pre-existing inverted Schneiderian papilloma in the left maxillary antrum and nasal cavity of a 72-year old male patient. Case Report:The patient had a significant history of radiotherapy for squamous cell carcinoma in the sinonasal area, 3 decades ago. The patient presented with chief complaints of left nasal blockage, nasal discharge, anosmia, and occasional epistaxis. Computed tomography scan displayed a lobular soft tissue mass resulting in narrowing of the nasopharyngeal airway with massive destruction of palatal tissue. The lesion was resected via endoscopic surgery. Macroscopically, a white fleshy appearance with necrosis was noted in the submitted specimen. Microscopically, the tumor was composed of pleomorphic epithelial and spindle cells with numerous mitoses and remarkable tissue necrosis. Residual inverted papilloma (IP) with high-grade dysplasia, and minimal foci of moderately differentiated squamous cell carcinoma (SCC) component was present at the tumor margin.A distinct zone of transition of SCC to spindle cell carcinoma (SpSCC) was noted and confirmed by focal positivity of p63 in epithelial and sacromatoid components. The pleomorphic sarcomatoid tumor was positive for vimentin with Ki67 highlighting 70% of tumor cells. A final diagnosis of sinonasal spindle cell carcinoma associated with residual inverted papilloma was rendered. Conclusions:Due to the rarity of such cases, the prognosis and response to treatment is unclear. No effective directed treatment has been developed. Unfortunately, the patient refused any further treatment and died of persistent disease. To the best of our knowledge, only one case of sinonasal carcinosarcoma arising from dysplastic inverted papilloma has been reported. The distinct possibility of previous radiotherapy contributing to development of sarcomatoid features in this neoplasm should also be considered.

show abstract

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

show abstract

Immune-related adverse event in the emergency department: methodology of the immune-related emergency disposition index (IrEDi)

Reyes-Gibby,

Caterino,

Coyne

et al. 2024

Emerg Cancer Care

View full text Add to dashboard Cite

For many cancer patients, immune checkpoint inhibitors (ICIs) can be life-saving. However, the immune-related adverse events (irAEs) from ICIs can be debilitating and can quickly become severe or even be fatal. Often, irAEs will precipitate visits to the emergency department (ED). Therefore, early recognition and the decision to admit, observe, or discharge these patients from the ED can be key to a cancer patient’s morbidity and mortality. ED clinicians typically make their decision for disposition (admit, observe, or discharge) within 2–6 h from their patient’s ED presentation. However, irAEs are particularly challenging in the ED because of atypical presentations, the absence of classic symptoms, the delayed availability of diagnostic tests during the ED encounter, and the fast pace in the ED setting. At present, there is no single sufficiently large ED data source with clinical, biological, laboratory, and imaging data that will allow for the development of a tool that will guide early recognition and appropriate ED disposition of patients with potential irAEs. We describe an ongoing federally funded project that aims to develop an immune-related emergency disposition index (IrEDi). The project capitalizes on a multi-site collaboration among 4 members of the Comprehensive Oncologic Emergency Research Network (CONCERN): MD Anderson Cancer Center, Ohio State University, Northwestern University, and University of California San Diego. If the aims are achieved, the IrEDi will be the first risk stratification tool derived from a large racial/ethnically and geographically diverse population of cancer patients. The future goal is to validate irEDi in general EDs to improve emergency care of cancer patients on ICIs.

show abstract

Complex Management of Brain Metastases in Head and Neck Squamous Cell Carcinoma: A Case Report and Literature Review

Corazzelli,

Russo,

Corvino

et al. 2024

Cureus

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) can, in rare instances, metastasize to the CNS, which is often associated with a poor prognosis. We present the case of a 65-year-old male with a history of HNSCC who developed two enhancing brain lesions: one in the right parietal region and another in the right insular region. Initially, the patient was managed with CyberKnife radiosurgery targeting both lesions. However, he later experienced neurological symptoms, including confusion, gait instability, and a left Jacksonian march, primarily attributed to the progression of the right parietal lesion. Given this symptomatic presentation, surgical resection of the lesion was performed to confirm the diagnosis and provide symptomatic relief. The surgical approach was selected based on the patient’s clinical progression and imaging findings, with the goal of improving his quality of life. Despite surgical intervention, the patient’s condition deteriorated, and he passed away seven months later. This case illustrates the complexity of treating CNS metastases from HNSCC, highlighting the challenges in surgical decision-making and the role of adjuvant therapies. The rarity of CNS metastases in HNSCC adds to the difficulty of management, underscoring the importance of a multidisciplinary approach. Further investigation is needed to develop standardized treatment protocols for such rare presentations. CNS metastases in HNSCC are uncommon and typically indicate a poor outcome. This case reinforces the need for ongoing research to enhance management strategies and improve patient survival in similar cases.

show abstract

A Rare Case of Stage IV Basaloid Squamous Cell Cancer with Intrapulmonary and Brain Metastases

Cited by 3 publications

References 13 publications

Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma

Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma

Immune-related adverse event in the emergency department: methodology of the immune-related emergency disposition index (IrEDi)

Complex Management of Brain Metastases in Head and Neck Squamous Cell Carcinoma: A Case Report and Literature Review

Contact Info

Product

Resources

About