A Rare Case of Strongyloides Hyperinfection from Hypogammaglobulinemia

Strongyloidiasis is a parasitosis representing a significant public health problem in tropical countries. It is often asymptomatic in immunocompetent individuals but its mortality rate increases to approximately 87% in severe forms of the disease. We conducted a systematic review, including case reports and case series, of Strongyloides hyperinfection and dissemination from 1998 to 2020 searching PubMed, EBSCO and SciELO. Cases that met the inclusion criteria of the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist were analysed. Statistical analysis was performed using Fisher’s exact test and Student's t-test and a Bonferroni correction for all the significant values. A total of 339 cases were included in this review. The mortality rate was 44.83%. The presence of infectious complications, septic shock and a lack of treatment were risk factors for a fatal outcome. Eosinophilia and ivermectin treatment were associated with an improved outcome.

show abstract

Epidemiological and Clinical Profile of Strongyloidiasis - Experience From a Tertiary Care Centre

Dusi

Boda

Mohan

et al. 2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The objective of the study was to study the clinical presentations, predisposing factors, and underlying conditions associated with Strongyloidiasis. Methods: A prospective observational study was conducted from 2018 to 2021on patients who presented with medical complaints in a tertiary care hospital, and 19 were diagnosed with strongyloidiasis by stool wet mount examination. Other relevant details were collected to analyze the risk factors. Results: A total of 19 cases were found positive for strongyloidiasis. Males 13 (68.4%) were more and females 6 (31.6%), and most of them were above 50 years age group (73.7%). Among the cases, respiratory symptoms (42.1%) were predominantly observed, followed by gastrointestinal (31.6%). Multiple predisposing factors such as chronic obstructive pulmonary disease, corticosteroid usage, TB, diabetes, alcohol, and asthma have been identified in strongyloidiasis cases. Peripheral eosinophilia is a frequent finding in the complete blood picture. Conclusions: Strongyloidiasis should be strongly suspected in every immune compromised patient presenting with gastrointestinal, respiratory manifestations, or peripheral eosinophilia, and asymptomatic immune competent patients with comorbid conditions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A Rare Case of Strongyloides Hyperinfection from Hypogammaglobulinemia

Cited by 4 publications

References 9 publications

Strongyloides stercoralis Infection in Solid Organ Transplant Recipients: a Case-Cohort Report at a Single-Center Experience

Strongyloides stercoralis Infection in Solid Organ Transplant Recipients: a Case-Cohort Report at a Single-Center Experience

Severe strongyloidiasis: a systematic review and meta-analysis of 339 cases

Epidemiological and Clinical Profile of Strongyloidiasis - Experience From a Tertiary Care Centre

Contact Info

Product

Resources

About