A rare case of subcutaneous Sweet’s syndrome in a patient with chronic myelogenous leukemia: a case report and review of the literature

Abstract

Subcutaneous Sweet's syndrome (SS) is a rare variant of classic SS characterized by a neutrophilic infiltrate exclusively or predominantly in the subcutaneous tissue, with minimal or absent dermal involvement. We report the case of a patient with a history of chronic myelogenous leukemia who developed subcutaneous SS. Although it has been described in patients with myelodysplastic syndromes and acute myeloid leukemia, this is the first report, to our knowledge, of this rare entity occurring in the setting of a myeloproliferative disorder.

Bullous Sweet syndrome as a presentation of chronic myelogenous leukaemia

“…Another rare case of subcutaneous Sweet syndrome in a patient with CML published in 2014 described a patient who had been under treatment with imatinib for diagnosed CML since 2009 and developed characteristic skin lesions while on supportive treatment in the hospital. It is intriguing to know that her nodules responded to chemotherapy rather than with steroids 9. A case report showed the association of Sweet syndrome with drugs like hydralazine and mentioned previous associations with oral contraceptives, minocycline and trimethoprim/sulfamethoxazole as well,10 all of which were ruled out in our patient’s case.…”