A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation

Jain, Ayushi; Singh, Suresh; Singhal, Pawan; Sharma, Malvika

doi:10.1017/s002221511400293x

Cited by 11 publications

(4 citation statements)

References 14 publications

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“…Rhabdomyosarcomas are rarely found in the larynx, in which most of the cases of head and neck rhabdomyosarcomas occur in the orbit, nasopharynx, and nose [2,3]. A particular study undertaken over a period of 20 years reported that children presenting with head and neck rhabdomyosarcomas have a mean age of 5.3 years and a median age of four years.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor often resembles the muscle cells found in 7to 10-day-old embryos. The four principal histological variants of rhabdomyosarcoma consist of embryonal, alveolar, pleomorphic, and botryoid, whereby, in general, the embryonal and pleomorphic subtypes occur in the younger and older population, respectively [1,2]. Their clinical presentation may be distinguished from other laryngeal malignancies, in which some may present with subtle clinical signs.…”

Section: Introductionmentioning

confidence: 99%

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Embryonal Rhabdomyosarcoma: The Diagnostic Dilemma of a Rare Laryngeal Malignancy

Rosdi¹,

Asmi²,

Thong³

et al. 2022

Cureus

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The larynx and the remaining components of the upper aerodigestive tract collectively play an important role in undertaking respiration, phonation, and deglutition. Therefore, a variety of pathologies can present with similar symptoms. Systemic diseases, such as rheumatoid arthritis and relapsing polychondritis, may also manifest with laryngeal symptoms and findings, whereas rare pathologies may present with vague presentations. Such scenarios may be attributed to the consequent medical confusion and dilemma in reaching an accurate diagnosis. In this case report, an 11-year-old male presented with airway compromise symptoms, which were later identified and diagnosed as laryngeal embryonal rhabdomyosarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Embryonal Rhabdomyosarcoma: The Diagnostic Dilemma of a Rare Laryngeal Malignancy

Rosdi¹,

Asmi²,

Thong³

et al. 2022

Cureus

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“…They represent less than 1% of all laryngeal tumors. A variety of uncommon sarcoma subtypes arising from the submucosal connective tissue have been described in the larynx, mainly as case reports or small series including synovial sarcoma [54][55][56], well-differentiated and dedifferentiated liposarcoma [57][58][59], alveolar soft part sarcoma [60], low-grade fibro-myxoid sarcoma [61], embryonal rhabdomyosarcoma [62][63][64][65][66], Kaposi sarcoma [67], and undifferentiated sarcoma [68][69][70] (Figures 2 and 3). Synovial sarcoma represents an aggressive soft tissue tumor classically arising from mesenchymal tissue.…”

Section: Soft Tissue Sarcomasmentioning

confidence: 99%

Non-Squamous Cell Carcinoma of the Larynx: A State-of-the-Art Review

Chiesa‐Estomba

Barillari

Mayo‐Yáñez

et al. 2023

JPM

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(1) Background: Non-squamous cell laryngeal carcinoma includes endothelial tumors, such as minor salivary gland tumors, lymphoepithelial tumors, neuroendocrine tumors, soft and hard tissue sarcomas, and malignant melanomas. (2) Methods: A state-of-the-art review using the MEDLINE/PUBMED, Google Scholar, Ovid Medline, Embase, and Scopus electronic databases was performed. (3) Conclusions: In order to optimize overall treatment outcomes, a multidisciplinary, patient-centered approach to the management of non-SCC of the larynx must be adopted universally; a national or international registry on non-SCC laryngeal cancer can be useful to improve understanding about the behavior of this kind of tumor.

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“…Als seltene maligne Tumorentitäten, die primär in der Subglottis entspringen, können z. B. das Rhabdomyosarkom [76], das Neurofibrosarkom [77], ein lymphoepitheliales Karzinom [78], ein kleinzelliges Karzinom der Subglottis mit schlechter Prognose aufgrund einer raschen Fernmetastasierung [79] sowie primäre Schleimhautmelanome angeführt werden [80]. Metastatische Tumorabsiedlungen in den Larynx sind eine Rarität.…”

Section: Sonstige Tumoreunclassified

Subglottische Pathologien

Heyduck

Pickhard²,

Brosch

et al. 2019

Laryngo-Rhino-Otol

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ZusammenfassungSubglottische Pathologien sind sehr selten und manifestieren sich mit einem unspezifischen klinischen Erscheinungsbild in Form einer Gewebevermehrung auf Höhe des Ringknorpels bzw. der cranialen Trachea, was die Diagnose verschleiert. Typische Symptome solcher Patienten sind Heiserkeit, Reizhusten, ein Fremdkörpergefühl sowie Dyspnoe bzw. Stridor. Differenzialdiagnostisch kommen verschiedene Erkrankungen in Frage: Benigne Erkrankungen wie Folgen eines Traumas (z. B. Stenosen), Entzündungen (z. B. Pseudokrupp), rheumatische Erkrankungen (z. B. Granulomatose mit Polyangiitis) oder gutartige Tumore (z. B. Papillom, Hämangiom oder Granularzelltumor). Auch maligne Erkrankungen wie z. B. ein Plattenepithelkarzinom des Larynx, ein Chondrosarkom oder sehr selten eine laryngeale Lymphommanifestation müssen differenzialdiagnostisch in Erwägung gezogen werden. Idiopathische Formen ohne erkennbare Ursache sind ebenfalls denkbar. Zur Diagnosesicherung wird bei tumorösen Veränderungen in der Regel eine Probeexzision mit histologischer Aufarbeitung durchgeführt. Die Therapie erfolgt in Abhängigkeit vom histologischen Ergebnis – bei soliden tumorösen Erkrankungen üblicherweise chirurgisch oder durch eine Lokal- bzw. Systemtherapie im interdisziplinären Kontext.

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A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation

Abstract: While surgery has been successfully used to treat this neoplasm, combination therapy, as described in our study, also seems effective and has the added advantage of preserving laryngeal function.

Cited by 11 publications

References 14 publications

Embryonal Rhabdomyosarcoma: The Diagnostic Dilemma of a Rare Laryngeal Malignancy

Embryonal Rhabdomyosarcoma: The Diagnostic Dilemma of a Rare Laryngeal Malignancy

Non-Squamous Cell Carcinoma of the Larynx: A State-of-the-Art Review

Subglottische Pathologien

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