A rare case of thyrolipomatosis presenting with latent hyperthyroidism

Harisankar, Chidambaram Natrajan Balasubramanian

doi:10.4103/ijnm.ijnm_21_18

Indian J Nucl Med

2018

DOI: 10.4103/ijnm.ijnm_21_18

|View full text |Cite

A rare case of thyrolipomatosis presenting with latent hyperthyroidism

Chidambaram Natrajan Balasubramanian Harisankar

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

Paz-Ibarra,

Concepción-Zavaleta,

Mendoza-Quispe

et al. 2023

European Endocrinology

View full text Add to dashboard Cite

Thyrolipomatosis, a diffuse non-neoplastic infiltration of fatty tissue in the thyroid gland, is an extremely rare condition with only about 30 cases reported worldwide. A few of these cases report the concurrency of thyrolipomatosis and malignant neoplasms in the thyroid or colon, but never with tongue cancer. A 44-year-old female patient with an infiltrative tongue mass suggestive of carcinoma presented for an outpatient consultation. Cervical imaging revealed multiple lymphadenopathies and a multinodular goitre with diffuse fatty infiltration, suggestive of thyrolipomatosis. Surgical intervention included partial resection of the tongue and thyroid (left hemiglossectomy and right hemithyroidectomy, respectively) and lymphadenectomy. The thyroid specimen showed diffuse fat metaplasia of the stromal thyroid tissue, confirming incidental thyrolipomatosis. During post-operative follow-up, the patient presented with recurrence of squamous cell carcinoma as indicated by new right-sided thyroid nodules, left-sided lymphadenopathies with confirmatory biopsy, and a growing neck mass that became infected. The patient developed septic shock and later died. Thyrolipomatosis causes thyroid swelling and can be clinically detected as goitres or as an incidental finding. Diagnosis is suggested by cervical imaging (ultrasonography, computed tomography or magnetic resonance), but confirmation is histological after thyroidectomy. Although thyrolipomatosis is benign, it could develop concurrently with neoplastic diseases, especially on embryologically related tissues (e.g. thyroid and tongue). This case report is the first in the literature describing the coexistence between thyrolipomatosis and tongue cancer in an adult Peruvian patient.

show abstract

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

Paz-Ibarra,

Concepción-Zavaleta,

Mendoza-Quispe

et al. 2023

European Endocrinology

View full text Add to dashboard Cite

show abstract

Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review

Emmanouilidou,

Karanikas,

Pazaitou-Panayiotou

et al. 2024

JCM

View full text Add to dashboard Cite

Diffuse lipomatosis of the thyroid (DLT) is an uncommon condition where mature fat cells infiltrate the thyroid gland, disrupting its normal structure. Although rare, it typically manifests as neck enlargement or symptoms of compression, including breathing difficulties, trouble swallowing, and voice changes, which can complicate diagnosis. This report presents a case of a 61-year-old woman with DLT, who exhibited a multinodular goiter and progressive neck swelling, and examines 53 additional cases from the existing literature. The analysis indicates that DLT is frequently misdiagnosed because of its similarities with other thyroid disorders. The precise mechanism underlying its development remains uncertain, but theories include oxygen deprivation in tissues, developmental abnormalities, and disruptions in fat metabolism. Surgical removal is the preferred treatment, especially for patients experiencing symptoms, and has shown favorable long-term outcomes. Additional studies should aim to elucidate the exact cause of DLT and enhance diagnostic precision, particularly in distinguishing it from other fat-containing thyroid lesions such as amyloid goiter and adenolipomas. A deeper understanding of this condition will inform better treatment approaches and enhance patient outcomes for this uncommon but significant thyroid disorder.

show abstract

Diffuse Thyroid Lipomatosis and Amyloid Goiter With Incidental Papillary Thyroid Carcinoma: A Rare Case Report

George,

Shah

2024

Cureus

View full text Add to dashboard Cite

Lipoid lesions of the thyroid gland are very rare. Fat-containing thyroid lesions include a variety of clinical-pathological disorders, such as adenolipomas, thyrolipomatosis, and lipomatous tissue, in the event of amyloidosis. Herein, we report a case of diffuse thyrolipomatosis with amyloidosis and incidentally detected papillary carcinoma of the thyroid in a 51-year-old female patient who clinically presented with a multinodular goiter. Amyloidosis in papillary carcinoma of the thyroid is very rare and can be primary or secondary amyloidosis. Thyrolipomatosis, amyloid goiter, and papillary carcinoma of the thyroid is a rare combination, and to our knowledge, this is the third reported case in the literature. The association of amyloidosis and the rare occurrence of a differentiated carcinoma have to be considered, as in the case of thyroid lipomatosis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A rare case of thyrolipomatosis presenting with latent hyperthyroidism

Cited by 3 publications

References 7 publications

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

Coexistence of Thyrolipomatosis and Tongue Squamous Cell Carcinoma: A Case Report

Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review

Diffuse Thyroid Lipomatosis and Amyloid Goiter With Incidental Papillary Thyroid Carcinoma: A Rare Case Report

Contact Info

Product

Resources

About