A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents

Basiri, Keivan; Meidani, Mohsen; Rezaie, Farshid; Soheilnader, Shabnam; Fatehi, Farzad

doi:10.5114/ninp.2012.27180

Cited by 12 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, the most prevalent species isolated from clinical samples was C. albicans, followed by C. parapsilosis, C. tropicalis, and C. guilliermondii. Moreover, some uncommon yeasts including C. africana, T. asahii, and C. jirovecii isolated in the current study that were less reported from Iran so far (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 56%

Molecular Identification of Clinically Common and Uncommon Yeast Species

Shokohi

Moradi

Badram

et al. 2018

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: The incidence of fungal infections caused by the yeasts and yeast-like species increased dramatically in immunocompromised patients, during the past several decades. However, a few of yeast and yeast-like species may colonize in skin and mucous membranes of healthy individuals. Objectives: The current study aimed at accurately identifying yeast and yeast-like species from clinical samples by molecular methods. Methods: A total of 1200 clinical samples were collected from patients with suspected fungal infection and 110 (9.16 %) yeast and yeast-like strains isolated and identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), PCR amplification of hwp1 gene, and sequencing. Results: In total, Candida albicans (n = 46) was the most frequently isolated species followed by C. parapsilosis complex (n = 17), C. tropicalis (n = 13), C. guilliermondii (n = 12), C. glabrata (n = 4), C. krusei and C. famata each (n = 3), C. kefyr, C. haemulonii and Cutaneotrichosporon jirovecii each (n = 2), and C. stellatoidea, C. intermedia, C. sorbosivorans, C. africana, Pichia kudriavzevii, and Trichosporon asahii each (n = 1). Interestingly, C. haemulonii, a multidrug resistant fungus was isolated from cutaneous and sputum samples for the first time in Iran. Conclusions: Nowadays, with growing population at risk for fungal infections and the emergence of some less virulent or nonpathogenic and uncommon yeasts not readily distinguishable with phenotypic assays, the accurate identification using molecular methods are warranted.

show abstract

Section: Discussionmentioning

confidence: 56%

Molecular Identification of Clinically Common and Uncommon Yeast Species

Shokohi

Moradi

Badram

et al. 2018

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…CNS trichosporonosis is uncommon in both the immunocompromised and the immunocompetent host. Reports of this condition in the literature are limited to case reports (5,(7)(8)(9). CNS trichosporonosis is usually fatal.…”

Section: Discussionmentioning

confidence: 99%

Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient

Thien

Chung

Tan

et al. 2016

Transplant Infectious Dis

View full text Add to dashboard Cite

Trichosporon is an ubiquitous yeast that has emerged as an opportunistic pathogen in the immunocompromised host. We describe a case of invasive trichosporonosis in an allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient while on caspofungin antifungal prophylaxis. She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. She later developed 2 further episodes of invasive trichosporonosis involving the central nervous system. This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients.

show abstract

“…Central nervous system (CNS) trichosporonosis is a rare clinical manifestation associated with immunocompromised patients [ 18 ]. In fact, only a few clinical cases of this medical condition have been reported in the literature [ 2 , 4 , 18 – 25 ] and none of them was due to T. inkin .…”

Section: Introductionmentioning

confidence: 99%

“…Despite some controversies, triazoles appear to be the best first line antifungal therapy for invasive trichosporonosis, especially when T. asahii is involved [ 1 , 10 , 18 , 19 , 27 ]. In vitro studies suggest that voriconazole exhibits the best antifungal activity against different Trichosporon species, when compared to amphotericin B and fluconazole [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Trichosporon inkin meningitis in Northeast Brazil: first case report and review of the literature

et al. 2018

View full text Add to dashboard Cite

BackgroundTrichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Central nervous system trichosporonosis is a very rare clinical manifestation. In fact, only a few cases have been published in the literature and none of them was caused by Trichosporon inkin.Case presentationHere we report the first clinical case of meningoencephalitis due to this species in a female previously healthy patient under corticosteroids and antibiotics therapy for several months. She was submitted to an invasive procedure to remove a left sided acoustic neuroma and further developed a cerebrospinal fistula. After some days of the procedure, she presented a predominantly and intensive occipital holocranial headache, followed by vomiting, hyporexia, weight loss, asthenia, irritability, difficulty to concentrate and rotator vertigo. The patient further developed a cerebrospinal fistula in the occipital region and was submitted to a surgical correction. After several months of clinical interventions, she was diagnosed with CNS Trichosporonosis, after Magnetic Resonance Imaging and positive microbiological cultures obtained within two different occasions (2 weeks apart). Despite the antifungal therapy with Amphotericin B and Voriconazole, the patient did not survive.ConclusionsDespite CNS Fungal infections are mostly due to Cryptococcus spp., other emergent yeasts, such as T. inkin may be considered as a likely etiological agent. This is the first case report of CNS Trichosporonosis, where species identification was performed with rDNA sequencing.

show abstract

A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents

Cited by 12 publications

References 10 publications

Molecular Identification of Clinically Common and Uncommon Yeast Species

Molecular Identification of Clinically Common and Uncommon Yeast Species

Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient

Trichosporon inkin meningitis in Northeast Brazil: first case report and review of the literature

Contact Info

Product

Resources

About