A rare case of turmeric‐induced hepatotoxicity

Chand, Sheital; Hair, Christopher; Beswick, Lauren

doi:10.1111/imj.14727

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…The second case was of DILI with autoantibodies in a 55-year-old male with metabolic syndrome after ingestion of turmeric-based supplements for cardiovascular health[ 26 ]. Similar biopsy findings and clinical outcome related to turmeric-induced severe liver injury was reported by Chand et al[ 27 ]. The patient developed additional features of severe myalgia, skin rash, and arthritis which resolved with normalization of liver tests after turmeric supplement withdrawal.…”

Section: Ayurvedic Herbs With Potential Hepatotoxicitysupporting

confidence: 88%

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

Philips

Ahamed

Rajesh

et al. 2020

WJH

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With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring for liver disease patients, to support early identification and treatment of those who present with CAM-induced liver injury.

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Section: Ayurvedic Herbs With Potential Hepatotoxicitysupporting

confidence: 88%

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

Philips

Ahamed

Rajesh

et al. 2020

WJH

View full text Add to dashboard Cite

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“…The biological plausibility of the association between hepatitis and high concentrations of curcumin and piperine is under study (Bi et al, 2019;Lee, Ju-Hee, & Young-Joo, 2012). However, it should be outlined that recent literature supports the association between food supplements containing curcumin and cholestatic hepatitis (Burgos-Morón, Calderón-Montaño, Salvador, Robles, & López-Lázaro, 2010;Chand, Hair, & Beswick, 2020;Lombardi et al, 2020;Menniti-Ippolito et al, 2020;Suhail, Masood, Sharma, John, & Dhamoon, 2020).…”

Section: Hepatic Reactionsmentioning

confidence: 99%

Suspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance system

Ippoliti

Menniti‐Ippolito

Mazzanti

et al. 2021

Phytotherapy Research

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Herbal tonic and adaptogens are often used to improve overall well-being. However, few clinical evidence supports their use and their safety is not known before marketing. In this context, the aim of our study was to analyze the spontaneous reports of suspected adverse reactions (ARs) to performance enhancing herbal dietary supplements collected by the Italian Phytovigilance System. Between March 2002 and September 2020, 110 spontaneous reports were collected, 58 of which related to products containing botanicals, alone or in association. Twenty-three serious reactions were reported, 21 of which required hospitalization, one was life-threatening and another caused disability. Dermatological and cardiovascular reactions were the most frequent. Hepatic ARs were the most serious (9 out of 10). A positive dechallenge was indicated in 69% of cases, while a positive rechallenge occurred in 15%. Concomitant use of other products was present in 18 reports (31%), while predisposing conditions were indicated in 17 (29%). Present data highlight safety concerns on herbal dietary supplements used as cognitive and physical performance enhancers, mainly due to their quality and use without expert supervision. Considering that postmarketing surveillance is not required for these products, spontaneous reports represent the only tool to point out risks related to food supplements.

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“…Furthermore, other investigations suggested that high doses of curcumin can prompt gastrointestinal upset, skin inflammation [145], and advanced liver toxicity in humans [146]. Major pathogenetic factors which link obesity to metabolic diseases involve increasing levels of circulating free fatty acids, endoplasmic reticulum (ER) stress, altered levels of adipokines, decreased adiponectin, and infiltrating macrophage-derived cytokines, such as increased MCP-1, TNF- , and IL-6 [147][148][149][150][151][152][153][154].…”

Section: Curcuminmentioning

confidence: 99%

“…Major pathogenetic factors which link obesity to metabolic diseases involve increasing levels of circulating free fatty acids, endoplasmic reticulum (ER) stress, altered levels of adipokines, decreased adiponectin, and infiltrating macrophage-derived cytokines, such as increased MCP-1, TNF- , and IL-6 [147][148][149][150][151][152][153][154]. Furthermore, other investigations suggested that high doses of curcumin can prompt gastrointestinal upset, skin inflammation [145], and advanced liver toxicity in humans [146]. Major pathogenetic factors which link obesity to metabolic diseases involve increasing levels of circulating free fatty acids, endoplasmic reticulum (ER) stress, altered levels of adipokines, decreased adiponectin, and infiltrating macrophage-derived cytokines, such as increased MCP-1, TNF-α, and IL-6 [147][148][149][150][151][152][153][154].…”

Section: Curcuminmentioning

confidence: 99%

Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

et al. 2021

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Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years. The most nagging effects were found early in the cardiovascular system. However, later, its negative impact was also investigated in several other organs. Damage at cellular structures due to overexpression of reactive oxygen species together with mechanisms that cause under-production of antioxidants leads to the development of obesity-related complications. In this view, the negative results of oxidant molecules due to obesity were studied in various districts of the body. In the last ten years, scientific literature has reported reasonable evidence regarding natural and synthetic compounds’ supplementation, which showed benefits in reducing oxidative stress and inflammatory processes in animal models of obesity. This article attempts to clarify the role of oxidative stress due to obesity and the opposing role of antioxidants to counter it, reported in preclinical studies. This analysis aims to clear-up different mechanisms that lead to the build-up of pro-oxidants during obesity and how various molecules of different origins hinder this phenomenon, behaving as antioxidants.

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A rare case of turmeric‐induced hepatotoxicity

Cited by 8 publications

References 5 publications

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs

Suspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance system

Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

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