A Rare Case Report of Mucinous Cystadenoma with Immunohistochemical Analysis and Review of Literature

Abstract

Cystadenomas are rare salivary gland tumours characterised by prominent epithelium-lined papillary projections into the cystic spaces. A 37 year-old female, presented with a swelling on the right side of the hard palate. Clinically, the swelling was soft, fluctuant, sessile and non-tender measuring 2.5 9 2 cm in diameter. Excisional biopsy was performed. The histopathological and immunohistochemical features were characteristic of mucinous cystadenoma. There has been no recurrence over a 2-year follow up period. The article highlights its clinical, histopathological, immunohistochemical features and differential diagnosis along with review of literature. Cystadenoma of the palate is rare, papillary variety being more common than mucinous with very few cases reported in literature.

Mucinous Cystadenoma of Parotid Gland: A Rare Entity

“…3 In the present case, the swelling also developed as a painless small mass over the period of 3 years at the peri-auricular area, finally reaching the size of 5.5 cm. It has been documented that females are more commonly affected than males, especially in advanced age (>50 years), 7 but in the current case, the swelling developed in a male patient of 44 years old. Contrary results were obtained in a study performed by Perks et al, 8 who reported a case of cystadenoma (both mucinous and papillary components) in a 78-year-old male with a 3-month history of an asymptomatic palatal swelling.…”

“…A report from the Japanese population documented a slowly enlarging tumor, 10 mm in diameter, in the hard palate. 9 Another case published by Girotra et al 7 reported a non-tender swelling on the right side of the hard palate of a female patient. Yet another case reported a 2-year history of a slow-growing tumor in the left parotid gland but without any obvious clinical symptoms.…”

“…Mostly, the superficial parotidectomy is opted for surgical removal of these parotid adenomas 13 or a complete surgical excision of the tumor is undertaken depending upon its location. 7 Literature has shown that some of the cystadenomas may have a malignant potential based on the recurrence rate and extent of surgical excision of major salivary glands. 6 Surgical excision of the complete tumor with clear resection margins is advisable to avoid the transformation of a mucinous cystadenoma into a mucinous cystadenocarcinoma over the time period.…”

Papillary cystadenoma of the parotid gland: A case report

“…Recurrence is seldom seen, with more tumors recurring in major salivary glands than in minor ones. Inadequate removal due to an incomplete capsule or tumor cell infiltration of the parotid gland is probably responsible for recurrence[13,18]. Although cystadenoma of the salivary gland is a benign tumor, postoperative malignant transformation has been reported[19].…”