A rare case report of squamous-cell carcinoma arising from mature cystic teratoma of ovary

Kalampokas, Emmanouil

doi:10.11138/gchir/2014.35.9.241

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…An enhanced CT and MRI show higher resolution of the soft tissue and higher sensitivity to fat composition and calcification, but it is still difficult to predict the malignant transformation of a teratoma by CT and MRI scanning because of its complex tissue composition. When an enhanced CT or MRI shows a tumor diameter of ≥ 10 cm, cystic wall thickening, an unclear boundary, irregular lobulation, uneven solid component enhancement, transmural necrosis, surrounding tissue adhesion, and lymph node enlargement in the peritoneum, these symptoms indicate the possibility of invasive disease [5,11,12] . When compared with the traditional T1-weighted images, the fat-suppressed T1-weighted images show more clearly the contrast-enhanced solid part of the teratoma, which is helpful to predict the teratoma malignancy [7] .…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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A mature ovarian teratoma is a common benign germ cell tumor of the ovary in women that rarely causes a malignant transformation. However, a malignant transformation can occur in the ectodermal, mesodermal, and endodermal tissues of the tumor. A squamous cell carcinoma is the most common and an adenocarcinoma is the second most common malignant tumor derived from a cystic teratoma. Due to the rarity of malignant transformations in mature teratomas and the lack of clinical data, the clinical pathological features, malignant transformation mechanism, therapeutic methods, and prognosis-relevant factors are unclear. Currently, there is no specific diagnostic method, and it is a difficult lesion to diagnose before performing surgery. In order to improve clinicians' understanding of a malignant-transformed mature teratoma and identification of malignant-transformed teratomas at early stages, we have reported a case of a mature teratoma with the malignant transformation of a sebaceous gland carcinoma in the Yiwu Central Hospital in Zhejiang, China on May 31, 2018. A review of the literature is also presented to summarize the clinical symptoms, pathogenesis, diagnosis, and treatment of malignant-transformed mature teratomas.

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Section: Discussionmentioning

confidence: 99%

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Zhou

Jin

et al. 2018

Clin Surg Res Commun

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“…8 Squamous cell carcinoma was the most common malignant tumor seen in 5 cases, supporting previous findings reported in many literatures. [9][10][11] Carcinomas can arise from any of the mature epithelial tissue present. Apart from squamous cell carcinoma, other epithelial malignancies reported in MCT are basal cell carcinoma, sebaceous carcinoma, adenocarcinoma and neuroendocrine tumor.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation arising in mature cystic teratoma

2016

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Background: The prognosis of patients with malignant transformation arising within mature cystic teratoma is poor. However, preoperative diagnosis is dif cult due to its rarity. The aim of this study was to evaluate the clinical and histopathological characteristics of such malignancies. Materials and Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0. Results: Mature cystic teratoma comprised 230 cases (57.6%) out of total 399 cases of ovarian neoplasms. Malignant transformation was noted in 7 (3%) of the mature cystic teratoma. The mean age at diagnosis of patients with malignant transformation of mature cystic teratoma was 47.57 years. The size of the tumors ranged from 7-14cm. The mean diameter of tumor was 10.28cm. There was signi cant difference in age between mature cystic teratoma and malignant transformations arising within mature cystic teratoma. No signi cant association was noted in tumor size. Torsion was noted in a single case. Squamous cell carcinoma was the most common malignant tumor seen in 5 cases. The TNM stage distribution was T1aNx for 4 cases, T2aNx for one case and T3aNx for 2 cases. Conclusion: Squamous cell carcinoma is the most common malignancy arising in mature cystic teratoma. Advanced age is a signi cant risk factor for malignant transformation in mature cystic teratoma.

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“…Squamous cell carcinoma was the most common malignant tumor seen in 5 cases, supporting previous fi ndings reported in many literatures. 14,15 There was one case each of adenocarcinoma and carcinoid tumor. A study by Kikkawa et al, showed that a tumor diameter larger than 9.9cm had 86% sensitivity for malignancy in their series and concluded that older age, larger tumor and tumor demonstrating rapid growth should be suspected for malignancy.…”

Section: Discussionmentioning

confidence: 99%

A clinicopathologic evaluation of 230 cases of mature cystic teratomas

Sherpa

Baral

2016

Nepal j. obstet. gynaecol.

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Aims: Mature cystic teratomas, commonly known as dermoid cyst, is the most common benign tumor of ovary. The aim of this study was to evaluate the clinicopathologic behavior of mature cystic teratomas.Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0.Results: MCT comprised 230 (57.6%) out of total 399 cases of ovarian neoplasms. The age range of the patients was 8-74 years. The sizes of the tumors ranged from 2.5-20cm. 12% of the cases were bilateral. Ischemic modifications, presumably due to torsion, were noted in 10% of the cases, mostly in tumors larger than 10cm. None of the tumors of less than 5cm presented with signs of torsion. Malignant transformation was present in seven (3%) cases and was seen especially in older patients and in larger tumors. Squamous cell carcinoma was the most common malignant tumor seen in five cases. One case was a mixed germ cell tumor with components of MCT and yolk sac tumor.Conclusions: MCT is the most common germ cell tumor in patients of the reproductive age group. Complications such as torsion and malignant transformation occur mostly in larger tumors.

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A rare case report of squamous-cell carcinoma arising from mature cystic teratoma of ovary

Cited by 10 publications

References 21 publications

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Malignant Transformation of a Mature Ovarian Teratoma: A Case Report and Review of the Literature

Malignant transformation arising in mature cystic teratoma

A clinicopathologic evaluation of 230 cases of mature cystic teratomas

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