A rare cause of adult's epileptic crisis: Infratentorial multinodular and vacuolating neuronal tumor

Abdelouahhab, H.; Guemmi, I.; Bouamama, T.; Kamaoui, I.; Nasri, S.; Aichouni, Narjiss; Skiker, I.

doi:10.1016/j.radcr.2022.08.006

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…The vacuolar changes may be located in the cytoplasm or around the cell. Tumor cells are positive for SOX10, OLIG2, and HuC/HuD neuron-related markers, but NeuN is negative, indicating that these neuron-like cells may be immature neurons (8)(9)(10). Synaptophysin is expressed in the background glia of tumors but appears with light staining within the lesion nodules.…”

Section: Discussionmentioning

confidence: 99%

Case report: Rare case of multinodular and vacuolar neuronal tumors in the cerebellum

Wang,

2024

Front. Neurol.

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Multinodular and vacuolar neuronal tumor (MVNT) is a rare and benign neuroepithelial tumor. Most reports describe tumors located in the cerebral hemisphere. A literature review found that 15 cases were located in the posterior cranial fossa, but all lacked pathological evidence. In this case, a patient sought medical attention due to insomnia and irritability. Neuroepithelial tumors were found in the imaging, and the patient underwent radiation therapy. Three years later, malignant tumors were found upon imaging examination. After surgical resection and pathological testing, MVNT occurring in the cerebellum was diagnosed. MVNT is rare in the cerebellum, and direct imaging diagnosis becomes difficult after treatment. Therefore, our report of this case helps to further accurate understanding of the imaging, pathological, and molecular genetic changes occurring before and after MVNT treatment, and will improve the accuracy of pre-treatment diagnosis and reduce the likelihood of overtreatment.

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Section: Discussionmentioning

confidence: 99%

Case report: Rare case of multinodular and vacuolar neuronal tumors in the cerebellum

Wang,

2024

Front. Neurol.

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Multinodular and vacuolating posterior fossa lesions of unknown significance: a long-term observational study and literature review

Yasuoka,

Yamasaki,

Ozono

et al. 2024

Childs Nerv Syst

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Vermian multinodular and vacuolating lesion of unknown significance discovered following syncope: a case report

Passanisi,

Marrone,

Scalia

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance (MV PLUS) are benign cystic lesions that, though typically asymptomatic, can present with neurological symptoms such as seizures, headaches, and syncope. These lesions are predominantly found in sub-tentorial brain structures but can also appear in supratentorial areas. MRI is crucial in detecting these lesions, characterized by small nodules with high intensity on T2-FLAIR sequences. Despite increasing awareness, the pathophysiology and classification of MV PLUS lesions remain unclear, necessitating further research and careful monitoring. Case Presentation: A 52-year-old female presented with subjective dizziness and a recent syncope episode. Neurological examination showed ataxia and a positive Romberg sign. MRI revealed a multicystic and nodular lesion in the vermian and paravermian regions, with altered signal intensity on T1-weighted and FLAIR sequences. The lesion showed no pathological enhancement post-gadolinium administration, and spectroscopy revealed no significant metabolite peaks. Clinical improvement was observed following corticosteroid and antivertiginous therapy, and the patient was discharged with a recommendation for neuroradiological follow-up. Clinical Discussion: MV PLUS lesions are a subset of multinodular and vacuolating lesions that present significant diagnostic challenges due to their complex radiological features. First described in 2013, these lesions have distinct MRI characteristics, including nodular appearance with high T2-FLAIR intensity and occasional cystic components. Despite being benign and typically stable, the differential diagnosis includes various other intracranial lesions, requiring careful evaluation. The pathogenesis and optimal management strategies for MV PLUS lesions are still under investigation, emphasizing the need for continued research. Conclusion: MV PLUS lesions, though rare and benign, present unique diagnostic challenges due to their varied radiological features and potential neurological symptoms. Regular MRI monitoring is essential to track their stability, given the current lack of understanding regarding their pathophysiology and long-term implications. Further research is needed to elucidate the etiology, natural history, and optimal management of these intriguing lesions.

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A rare cause of adult's epileptic crisis: Infratentorial multinodular and vacuolating neuronal tumor

Cited by 4 publications

References 6 publications

Case report: Rare case of multinodular and vacuolar neuronal tumors in the cerebellum

Case report: Rare case of multinodular and vacuolar neuronal tumors in the cerebellum

Multinodular and vacuolating posterior fossa lesions of unknown significance: a long-term observational study and literature review

Vermian multinodular and vacuolating lesion of unknown significance discovered following syncope: a case report

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