A rare cause of lower GI bleeding

Waleed, Muhammad; Am, Ali; Saraj, O; Babu, Sathish; Morgan, Robert

doi:10.1136/bcr.03.2012.6086

Cited by 4 publications

(1 citation statement)

References 4 publications

(2 reference statements)

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“…Only nine cases were included in our review (reasons for exclusion were: baseline diagnosis of systemic amyloidosis in 29 cases, and in the other two cases, the presentation was not GI bleed). Of the nine cases, five were women and four were men, they all presented with gastrointestinal bleeding, with or without a previous diagnosis of multiple myeloma [11][12][13][14][15][16][17][18][19]. The GI bleed led to upper endoscopy and/or colonoscopy, where further GI pathology revealed amyloidosis.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Reactive Amyloid A (AA) Amyloidosis in a Patient With Multiple Myeloma: A Case Report and Literature Review

Rosado,

Taveras,

Gayam

et al. 2023

Cureus

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Amyloidosis is a rare group of disorders characterized by the extracellular deposition of misfolded protein aggregates that interfere with the function of the tissue affected. In some patients, the presenting symptom of monoclonal gammopathies, such as multiple myeloma, can be a gastrointestinal bleed with a further report of amyloidosis in gastrointestinal samples. In all the cases the pathology report is read as AL (light chain) amyloidosis. We present a case of a 57-year-old male patient with no medical history who debuted with gastrointestinal bleeding. A colonoscopy revealed a colonic ulcer with a pathologic diagnosis of amyloid A (AA) amyloidosis. Further investigation led to the finding of multiple myeloma (MM) with no evidence of systemic amyloidosis. Although there is little evidence in the literature of the association or even causative relationship between multiple myeloma and AA amyloidosis, our case highlights the importance of searching for an underlying monoclonal gammopathy like MM in a patient with a confirmed diagnosis of AA amyloidosis.

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Section: Discussionmentioning

confidence: 99%

Intestinal Reactive Amyloid A (AA) Amyloidosis in a Patient With Multiple Myeloma: A Case Report and Literature Review

Rosado,

Taveras,

Gayam

et al. 2023

Cureus

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Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review

Huang

et al. 2020

Arab Journal of Gastroenterology

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A rare case of multiple myeloma with several atypical manifestations

Nasti,

Natale,

Morena

et al. 2024

Ital J Med

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A 75-year-old woman presented asthenia and anemia after recurrent intestinal bleeding. Colonoscopy showed the presence of blood clots in the ascending colon, without active bleeding. During hospitalization, right toe cyanosis progressed to ischemic necrosis and was resistant to analgesics and vasodilators. The positron emission tomography-computed tomography scan showed a nodular thickening in the midfield of the right lung. Blood chemistry evidenced an Immunoglobulin (Ig) G-λ monoclonal peak. Multiple myeloma (MM) was diagnosed by bone marrow biopsy and serum/urine Ig-free chain dosage. The patient no longer had intestinal bleeding after the first MM chemotherapy (CHT). After 6 months of CHT, a partial hematological response and peripheral vascular improvement occurred. Extremely rare conditions may result in MM. In this case report, seemingly unrelated atypical manifestations co-existed and responded to hematological CHT for MM, confirming their association with the disease.

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A rare cause of lower GI bleeding

Cited by 4 publications

References 4 publications

Intestinal Reactive Amyloid A (AA) Amyloidosis in a Patient With Multiple Myeloma: A Case Report and Literature Review

Intestinal Reactive Amyloid A (AA) Amyloidosis in a Patient With Multiple Myeloma: A Case Report and Literature Review

Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review

A rare case of multiple myeloma with several atypical manifestations

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