A rare cause of obstructive jaundice: Fasciola hepatica mimicking cholangiocarcinoma

Yalav, Orçun; Yağmur, Özgür; Ülkü, Abdullah; Akçam, Atılgan Tolga; Sönmez, Hüsnü

doi:10.4318/tjg.2012.0420

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…In this study, no change in the value of AFP and CEA was observed for all the rabbit sera. Our data are in agreement with previous case reports indicating that tumor markers including AFP and CEA were at normal value in human fascioliasis [ 1 , 14 , 15 , 28 ]. This suggested that there might be no relationship between fascioliasis and cholangiocarcinoma, at least at the acute phase.…”

supporting

confidence: 93%

Dynamics of liver enzymes in rabbits experimentally infected with <i>Fasciola</i> sp. (Intermediate form from Japan)

Jarujareet

Taira

Ooi

2018

The Journal of Veterinary Medical Science

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Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct. However, no significant increase in serum gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were observed. This could reflect reduced or minimal injury of bile ducts and biliary epithelia as the flukes had reached the adult stage. Alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) were not detected in the infected rabbit during the course of the experiment. Serum liver enzymes monitoring might be useful for understanding the host-parasite relationship in fascioliasis.

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supporting

confidence: 93%

Dynamics of liver enzymes in rabbits experimentally infected with <i>Fasciola</i> sp. (Intermediate form from Japan)

Jarujareet

Taira

Ooi

2018

The Journal of Veterinary Medical Science

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“…Indirect haemagglutination (IHA – commercialized: Fumouze Diagnostics) (see numerous references in Esteban et al 1998). The IHA test is a technique still used frequently in endemic areas, using purified adult F. hepatica F 1 as antigen (El-Shazly et al 2002; Haseeb et al 2003 b ; El-Ahl et al 2007; Hammami et al 2007; Deveci et al 2011; Gökçe et al 2011; Kaya et al 2011; Sakru et al 2011; Tanir et al 2011; Karadağ-Öncel et al 2012; Yalav et al 2012). Haemolysis tests.…”

Section: Diagnosis With Blood Samplesmentioning

confidence: 99%

Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario

2014

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Before the 1990s, human fascioliasis diagnosis focused on individual patients in hospitals or health centres. Case reports were mainly from developed countries and usually concerned isolated human infection in animal endemic areas. From the mid-1990s onwards, due to the progressive description of human endemic areas and human infection reports in developing countries, but also new knowledge on clinical manifestations and pathology, new situations, hitherto neglected, entered in the global scenario. Human fascioliasis has proved to be pronouncedly more heterogeneous than previously thought, including different transmission patterns and epidemiological situations. Stool and blood techniques, the main tools for diagnosis in humans, have been improved for both patient and survey diagnosis. Present availabilities for human diagnosis are reviewed focusing on advantages and weaknesses, sample management, egg differentiation, qualitative and quantitative diagnosis, antibody and antigen detection, post-treatment monitoring and post-control surveillance. Main conclusions refer to the pronounced difficulties of diagnosing fascioliasis in humans given the different infection phases and parasite migration capacities, clinical heterogeneity, immunological complexity, different epidemiological situations and transmission patterns, the lack of a diagnostic technique covering all needs and situations, and the advisability for a combined use of different techniques, at least including a stool technique and a blood technique.

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“…Chronic disease is present if signs and symptoms persist for more than 4 months or there are motile echogenic images in the gallbladder (Saba et al 2004). F. hepatica can localize to the lumen of the common bile duct (Kim et al 2006) and may cause common bile duct obstruction (Dobrucali et al 2004;Gulsen et al 2006;Caprino et al 2007), sometimes mimicking cholangiocarcinoma (Yalay et al 2012). Biliary fascioliasis rarely causes hemobilia (Wong et al 1985;Bahcecioglu et al 2007).…”

Section: Clinical Featuresmentioning

confidence: 99%

“…5 and 6;Cabanillas et al 1989). Intrahepatic multiple ill-defined hypoattenuating lesions and filling defects of the lesion lumens may mimic intrahepatic cholangiocarcinoma (Adachi et al 2005;Kim et al 2005;Yalay et al 2012). Rarely, F. hepatica infestation results in the formation of huge and multilocular Fig.…”

Section: Hepatobiliary Alterationsmentioning

confidence: 99%

Tumor-like Parasitic Lesions of the Hepatobiliary Tract: Liver Flukes and Other Trematodes

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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A rare cause of obstructive jaundice: Fasciola hepatica mimicking cholangiocarcinoma

Cited by 10 publications

References 17 publications

Dynamics of liver enzymes in rabbits experimentally infected with <i>Fasciola</i> sp. (Intermediate form from Japan)

Dynamics of liver enzymes in rabbits experimentally infected with <i>Fasciola</i> sp. (Intermediate form from Japan)

Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario

Tumor-like Parasitic Lesions of the Hepatobiliary Tract: Liver Flukes and Other Trematodes

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