A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma

Özden, Sabri; Güreşçi, Servet; Saylam, Barış; Dağlar, Gül

doi:10.1016/j.anl.2018.05.001

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…In a case series of 21 patients, only 12 (57%) parathyroid lipoadenomas could be identified with Tc-99m sestamibi . Other case reports support the inability to identify parathyroid lipoadenomas using this modality . Therefore, these results show the necessity of using other imaging modalities to locate this less common variant.…”

Section: Discussionmentioning

confidence: 83%

“…1 Other case reports support the inability to identify parathyroid lipoadenomas using this modality. [2][3][4][5] Therefore, these results show the necessity of using other imaging modalities to locate this less common variant.…”

Section: Discussionmentioning

confidence: 83%

“…Obesity and advanced age may increase this percentage of fatty tissue. Only 70 cases of parathyroid lipoadenoma have been described to date, [1][2][3][4][5] accounting for less than 1% of all cases of hyperparathyroidism, and most ectopic locations have been in the mediastinum. 6 Of note, although a liposarcoma may have similar imaging findings to a lipoadenoma, corresponding primary hyperparathyroidism would be unlikely.…”

Section: Discussionmentioning

confidence: 99%

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An Unusual Retropharyngeal Lesion

Yang

Novinger

Sim

2021

JAMA Otolaryngol Head Neck Surg

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An Unusual Retropharyngeal Lesion

Yang

Novinger

Sim

2021

JAMA Otolaryngol Head Neck Surg

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“…After excluding 18 cases with missing clinical data, 47 cases had complete clinical data, including 30 females and 17 males, with a female‐to‐male ratio of about 1.8:1, that is, parathyroid lipoadenoma accounted for a higher proportion in females than in males. In addition, it has been reported in the literature that parathyroid lipoadenoma may account for a higher proportion in males than parathyroid adenoma 2 . The age of onset of parathyroid lipoadenomas varies from 24 to 88 years, mostly located in the neck, but up to 15% of parathyroid lipoadenomas are ectopic or located in the mediastinum, much higher than common parathyroid adenomas 3 …”

Section: Discussionmentioning

confidence: 99%

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Wang,

Chen,

2023

Clinical Case Reports

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Key Clinical MessageParathyroid lipoadenoma is a rare type of parathyroid adenoma, described as a single parathyroid adenoma with more than 50% fat on histologic examination and an unknown etiology, which is one of the rare causes of primary hyperparathyroidism. The difficulty of parathyroid lipoadenoma is mainly diagnosed by preoperative imaging localization. We hope to arouse attention to the parathyroid adenoma which is difficult to locate through our case report. The patient was a middle‐aged male with a body mass index of 38.4 kg/m2 who admitted to our hospital with a 40‐day history of an untreated thyroid nodule. We incidentally discovered parathyroid lipoadenoma in his thyroid surgery. His prognosis was good, and there were no signs of recurrence at his 12‐month follow‐up appointment. We believe that parathyroid lipoadenoma needs to rely on paraffin pathology to make a final diagnosis. This case report serves as a reminder that parathyroid lipoadenomas are also possible in patients who do not have primary hyperparathyroidism preoperatively and who have negative imaging. Clinicians must carefully examine the adipose tissue for the presence of parathyroid lipoadenomas during thyroid surgery to avoid postoperative hypoparathyroidism and persistent hypocalcaemia.

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“…Since lipoadenomas can mimic normal parathyroid tissue at histology, pathologists need to be aware of this lesion especially during intraoperative sections. A conclusive parathyroid vs stromal fat cells ratio to distinguish lipoadenomas from normal glands is not yet defined, although some authors reported using fat cells percentages cut-offs ranging from 30 to 50% [ 7 , 8 ]. Therefore, a definitive diagnosis of functioning parathyroid lipoadenoma usually comprises the pathologic diagnosis of a parathyroid proliferation within a fatty stroma combined with a significant intraoperative PTH drop after the excision [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Atypical primary hyperparathyroidism due to parathyroid lipoadenoma: a case report

Cammarata

Yakushkina

Pennacchi

et al. 2021

Journal of Surgical Case Reports

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Parathyroid lipoadenoma is a very rare cause of primary hyperparathyroidism. Preoperative imaging techniques often fail to detect such lesions, and even during surgery they can be misinterpreted just as fat tissue. A 62-year-old woman clinically monitored for primary hyperparathyroidism, with hypertension and a left nephrectomy for hydrouretheronephrosis caused by recurrent kidney stones. A neck ultrasound showed a nodule consistent with left parathyroid of 9 × 5 mm, which was not confirmed on single-photon-emission computed tomography/computed tomography (CT) scan. On surgery, a voluminous lesion with adipose appearance and texture was removed. Frozen sections and intraoperative parathyroid hormone (PTH) confirmed such lesion to be a parathyroid lipoadenoma. Parathyroid lipoadenomas are difficult to localize preoperatively. Sometimes they can be seen by ultrasound scan as hyperechoich lesion, but scintigraphy and CT often fail to identify them. Only the awareness of such lesions and the use of intraoperative PTH can avoid unnecessary extensive cervical exploration.

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A rare cause of primary hyperparathyroidism: Parathyroid lipoadenoma

Cited by 12 publications

References 12 publications

An Unusual Retropharyngeal Lesion

An Unusual Retropharyngeal Lesion

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

Atypical primary hyperparathyroidism due to parathyroid lipoadenoma: a case report

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