A rare coexistence of aspergillosis with actinomycosis

Abstract

Aspergillosis is a common systemic mycosis which affects immunocompromised and immunocompetent hosts. Aspergillus spp. is wide spread in the environment in most countries, which renders an invasive form of disease. The presence conidial heads are pathognomic to aspergillosis in diagnosis. Actinomycosis is a subacute-to-chronic infection that causes sinus fistula, tract or abscess due to the invasion surrounding the soft tissue. Cervicofacial infection accounts for 50%–60% of all actinomycosis cases. The mandible and nasopharynx are the sites of predilection, but maxillary infection is rare. Aspergillosis and Actinomycosis each of them was reported in case, but mixed infection of both organisms is rare, only one case has been reported. This paper discussed about a case report of coexistence of aspergillosis with actinomycosis in 38-year-old male.

Osteoma with actinomycosis in a nasal cavity

“…[ 1 ] It is an anaerobic Gram-positive bacteria and a normal saprophytic organism in the mouth, colon, and vagina. [ 12 ] Clinical manifestations of actinomycosis are divided into 3 forms: cervicofacial, thoracic, and abdominopelvic. [ 13 ] It can occur both in immunocompromised patients and in immunocompetent patients with a history of trauma.…”

Clinicopathological features of 214 maxillary sinus pathologies. A ten-year single-centre retrospective clinical study

“…The demonstration of hyphae and the lack of eosinophils in the mucus of these patients differentiates this condition from allergic fungal sinusitis. Its infection can coexist with other processes, such as non-specific bacterial sinusitis and less frequently with actinomyces [18]. Mucormycosis, on the other hand, is an angioinvasive fungal infection associated with high morbidity and mortality.…”

Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections

“…Aspergillosis represents the second most common type of opportunistic fungal infection after candidiasis [ 20 , 43 , 44 , 45 ]. As the name suggests, this oral mycosis is caused by Aspergillus spp., with the most frequently identified species being Aspergillus fumigatus , Aspergillus flavus , Aspergillus niger , and Aspergillus terreus [ 20 , 45 ].…”

“…Hence, Aspergillus spp. first causes rhinosinusitis and broncho-pulmonary infections that may further spread to the skin, orbits, nose, larynx, and palate [ 44 , 45 , 46 ]. Tissue invasion is uncommon in immunocompetent individuals, but life-threatening complications can occur in patients with HIV infection, hematological malignancies, diabetes mellitus, or drug-induced immunosuppressive states [ 20 , 43 , 44 , 46 ].…”

“…Tissue invasion is uncommon in immunocompetent individuals, but life-threatening complications can occur in patients with HIV infection, hematological malignancies, diabetes mellitus, or drug-induced immunosuppressive states [ 20 , 43 , 44 , 46 ]. This happens because in healthy people acquiring this infection the inhaled fungus is destroyed by macrophages and neutrophils, whereas in immunocompromised patients microorganisms may pass through without being intercepted due to neutropenia or neutrophil dysfunction [ 44 , 45 ].…”