A rare endoscopic appearance of granulomatosis with polyangiitis involving the intestine: a case report

Abstract

BackgroundThe involvement of granulomatosis with polyangiitis is less frequent in the intestine.Case presentationWe present a case of Wegener’s granulomatosis with unusual endoscopic appearance, involvement in a young man’s gastrointestinal tract. A 45-year-old man was diagnosed with Wegener’s granulomatosis 11 years ago, and relapsed with abdominal pain and melena. A colonoscopy was performed, and the appearance of mucosal lesions with an unusual annular black membrane was observed. A black ring-shaped membranous tissue adhered to the surface of the colon wall, which could be traversed by an endoscopic forepart.ConclusionBiopsy of the black membrane revealed degenerative colonic mucosal tissues, while deep colonic biopsy revealed inflammatory granulation tissues. This has not been reported in previous documents.

Colorectal surgical management of colitis induced by vasculitis in the absence of inflammatory bowel disease: a case report and literature review

“…4 for a PRISMA flowchart). The average patient age was 49 years, and a half (10 of 20) of the patients were female (Table 1 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]). No patient was reported to have colitis induced by large artery disease (giant cell arteritis, Takayasu arteritis, or isolated aortitis).…”

“…Eighteen (90.0%) patients received CT for investigation, and 17 (85.0%) underwent a colonoscopy or sigmoidoscopy (Table 2) [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Patients received between 1 and 3 colonoscopies or sigmoidoscopies, with an average of 1.3 per patient.…”

“…The median length of stay was 40.5 days (Table 3) [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. One patient with SLE developed hospital-acquired pneumonia and gram-negative septicemia [21].…”

“…Ninety-five percent of patients received immunosuppression (either initial or after the index operation). Steroids (70.0%) were the most common medical therapy, followed by DMARDs (60.0%), monoclonal antibodies (15.0%), and plasmaphereses (10.0%) [14][15][16][17][18][19][21][22][23][24][25][26][27][28][29][30][31][32]. The timeframe of failed medical therapy was variable (7-66 days) [14,20,29,30].…”

Granulomatosis with Polyangiitis with Intestinal Perforations as Complications: Case Report

“…Final histopathological diagnosis: Intestinal perforation with transluminal enteritis and acute peritonitis. in recent reports the gastrointestinal illness includes: submucosal edema, ulcers, hemorrhage, mesenteric ischemia, intestinal obstruction and perforation [4][5][6]. Colonic perforation associated with cytomegalovirus infection in immunocompromised patients (kidney transplant, systemic erythematosus lupus, HIV infection) precipitated by treatment with steroids has been documented in literature, however literature regarding GPA has not been found [7].…”