A rare highly aggressive tumor of the kidney: The pure epithelioid angiomyolipoma

Bani, Mohamed Amine; Laabidi, Besma; Rejeb, Sarra Ben; Khiari, Ramzi; Bouziani, A.; Msakni, Issam

doi:10.1016/j.eucr.2018.03.007

Cited by 2 publications

(4 citation statements)

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“…Diagnosis of renal angiomyolipoma is considered to be relatively easy because of the presence of fatty cells is found (13). On the other hand, the epithelioid type of angiomyolipoma is challenging in most cases as it can mimic a majority of neoplasms, especially renal cell carcinoma (12). In our case, the tumour was first considered to be renal cell carcinoma and the diagnosis of epithelioid angiomyolipoma was only later confirmed by the histological analysis.…”

Section: Discussionmentioning

confidence: 72%

“…In his study, four characteristics were found significant in predicting malignant EAML behaviour: tumour size >9 cm, tumour thrombus formation in the vein, epithelioid cells >70% or atypia cells >60%, and necrosis. (16) In a case by Amine Bani et al necrosis, high mitosis index, marked atypia, vascular involvement, and predominant component of epithelioid cells were associated with malignancy and tumour progression (12). Recent studies by Jun Lei et al demonstrated the role of HMB45 biomarker in predicting EAML malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its malignant behaviour, factors which determine the risk of malignancy in patients presenting with EAML were searched for (15). There are no definite histological criteria for malignancy except distant metastases, which confirm malignant EAML (12). However, few factors (a high percentage of epithelioid cells, marked atypia and large diameter of the mass) have been associated with EAML malignancy by Jun Lei et al (16).…”

Section: Discussionmentioning

confidence: 99%

“…Presenting symptoms include: body weight loss, haematuria, abdominal pain, and cough in the advanced disease (11). In addition, patients with EAML frequently express lumbar pains (12). EAML should be taken into consideration by clinicians if the patient is of young age and the renal tumour is large in size (1).…”

Section: Introductionmentioning

confidence: 99%

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Partial nephrectomy can be a successful treatment option for renal epithelioid angiomyolipoma: a case report and literature review

Liulytė¹,

Žalimas²,

Meškauskas³

et al. 2020

AML

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Background. Renal epithelioid angiomyolipoma is a rare tumour which involves kidneys in most cases. It is known for its aggressive behaviour as a significant number of cases have been associated with metastatic epithelioid angiomyolipoma. Usually, radical treatment with systemic therapy is recommended. Only a small number of cases of epithelioid angiomyolipomas have been reported with the standard treatment being radical or partial nephrectomy. We present a case report showing that partial nephrectomy can be a successful treatment option for renal epithelioid angiomyolipoma. This is the first case of this nature in Lithuania. Case presentation. In this case, a 40-year-old male with epithelioid angiomyolipoma of the left kidney is presented. In 2012, a cystic left renal mass 40 × 41 mm in size was diagnosed incidentally while performing ultrasound and later confirmed by MRI. Due to the size of the tumour and the possibility of renal cell carcinoma, surgery was scheduled. Left partial nephrectomy was performed successfully. Final pathology report came back with the diagnosis of renal epithelioid angiomyolipoma. The patient had yearly follow-up for six years by CT scan, and neither recurrence nor progression were observed. Conclusion. Early detection and diagnosis are crucial for treatment as the tumour tends to have malignancy potential. With early diagnosis, partial nephrectomy can be performed with yearly follow-up and no systemic treatment required.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%