A rare lesion of cervical lymph nodes: Angiomyomatous hamartoma

Abstract

Objective: Angiomyomatous hamartomas are extremely rare, tumor-like lesions of the lymph nodes. They are usually seen in the inguinal region lymph nodes. They are rarely seen in the lymph nodes of the cervical region. Histopathologically, fibrous tissues, smooth muscle cells, and vascular structures are seen in the lymph node structure. It is important to distinguish it from benign and malignant lesions of the lymph node.
 Case: A 1 cm diameter lymph node excision material removed from the cervical region of a 26-year-old male patient was sent to the pathology laboratory with a pre-diagnosis of lymphadenitis. 4- micron sections were taken from the paraffin blocks prepared from the tissues belonging to the lesion. The samples were examined by staining Hematoxylin-Eosin. In histopathological examination, it was found that almost all of the lymph node structure consisted of vascular structures and smooth muscle cells located on a fibrous ground. The case was reported as angiomyomatous hamartoma.
 Conclusion: Angiomyomatous hamartomas are extremely rare lesions of the cervical lymph nodes and their consideration in differential diagnosis will reduce the risk of possible diagnostic error.

A rare case of angiomyomatous hamartoma in the pelvic and paraaortic lymph nodes

“…Angiomyomatous hamartoma of the lymph node most often involves the inguinal or femoral lymph nodes, rarely affecting more than one. Other locations have been described as well – 4 cases of lymph node involvement in the pelvis, only 1 in women [ 6 – 10 ], 3 cases of cervical lymph node involvement [ 4 , 11 , 12 ], 2 cases of post-auricular lymph node involvement, both in men [ 13 , 14 ] and 3 cases in men with paraaortic and/or pelvic lymph node involvement [ 2 , 15 , 16 ]. The pathogenesis of this disease is unclear, suggesting that it may be a secondary response to inflammation of the lymph nodes responding to vascular proliferation [ 9 ].…”

“…Angiomyomatous hamartoma of the lymph node can affect people at any age but is considered to most commonly affect people in their 60s [ 26 ]. The youngest patient reported was 8 months old with an enlarged cervical lymph node [ 12 ]. The disease usually persists for years and does not recur after resection of the affected lymph node.…”