2018
DOI: 10.1155/2018/6892783
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A Rare Malignant Transformation of an Ovarian Cystic Teratoma: A Case Report

Abstract: Mature cystic teratoma (MCT) is the commonest germ cell neoplasm of the ovary but malignant transformation is a rare occurrence (1-2%). Of these malignancies documented in literature the commonest are squamous cell carcinoma and adenocarcinoma. Urothelial carcinomas arising in an MCT are a rare occurrence and only 7 cases have been reported in literature. We report a case of an MCT which was complicated by the presence of urothelial carcinoma confirmed on histopathological examination.

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Cited by 6 publications
(4 citation statements)
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“…Malignant transformation occurs in 0.17-2% of MCTs, and is rarely recognized preoperatively [4,12,13]. Of these malignant transformations, urothelial carcinomas arising from MCT are extremely rare, and only eight such cases have been reported in the literature to date [4][5][6][7][8][9][10][11]. Urothelial carcinoma of the ovary has been described as a primary ovarian carcinoma with definite urothelial features but no benign, metaplastic, and/or proliferating Brenner tumor identified [14].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Malignant transformation occurs in 0.17-2% of MCTs, and is rarely recognized preoperatively [4,12,13]. Of these malignant transformations, urothelial carcinomas arising from MCT are extremely rare, and only eight such cases have been reported in the literature to date [4][5][6][7][8][9][10][11]. Urothelial carcinoma of the ovary has been described as a primary ovarian carcinoma with definite urothelial features but no benign, metaplastic, and/or proliferating Brenner tumor identified [14].…”
Section: Discussionmentioning
confidence: 99%
“…More than 80% of MCT malignant transformations are squamous cell carcinomas (SCCs) arising from the ectoderm, and most of the remaining are carcinoid tumors or adenocarcinomas [4]. Urothelial carcinomas arising from an MCT are extremely rare and very few have been reported in the literature [4][5][6][7][8][9][10][11]. Here, we present the case of a woman with an incidental finding of a urothelial carcinoma arising from a left ovarian MCT, who underwent successful surgical treatment.…”
Section: Introductionmentioning
confidence: 99%
“…Less frequent histologic types include adenocarcinoma, sarcomas, thyroid carcinoma, malignant melanoma, and neuroectodermal tumors, among others (Table 1). 10,13–56 Carcinomas can arise from any mature epithelial tissue. Squamous cell carcinoma in mature cystic teratoma arises from the epidermal component via a carcinoma in situ pathway, or from the respiratory epithelium via squamous metaplasia/dysplasia/carcinoma in situ pathway 2,7,11 .…”
Section: Histopathologymentioning
confidence: 99%
“…Sebaceous gland carcinomas have a worse prognosis; therefore, under comprehensive consideration, a total hysterectomy combined with an omentectomy and pelvic lymph node dissection was conducted. A malignant transformation can occur in any mature teratoma tissue [16] . In this case, the malignant transformation occurred in the sebaceous glands of the teratoma tissue.…”
Section: Yun-xiao Zhou Et Al 24mentioning
confidence: 99%