A rare presentation of acute hyperglycemia with secondary mania: a case report

Padma, K; Fernandes, Sharol Lionel; Hegde, Shruti

doi:10.18203/2320-6012.ijrms20195557

Cited by 1 publication

(1 citation statement)

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“…Cross-sectionally, previous studies found hyperglycemia to be associated with depressive symptoms (Geraets et al ., 2020; Beran et al ., 2022). However, some case reports related acute hyperglycemia to the onset of manic states with psychotic symptoms in patients with T1DM (Sahoo et al ., 2016; Padma et al ., 2019).…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes mellitus is associated with manic morbidity in elderly patients with mood disorders

Weiss,

Brancati,

Elefante

et al. 2023

International Clinical Psychopharmacology

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The association between mood disorders, especially bipolar disorder (BD), and metabolic disorders, is long known. However, to which extent metabolic disorders affect the course of mood disorders in late life is still open to inquiring. To assess the impact of type 2 diabetes mellitus (T2DM) on late-life mood disorders a retrospective chart review was performed. Elderly depressive patients (≥ 65 years) diagnosed with Major Depressive Disorder (N = 57) or BD (N = 43) and followed up for at least 18 months were included and subdivided according to the presence of T2DM comorbidity. Vascular encephalopathy (39.1% vs. 15.6%, P = 0.021) and neurocognitive disorders (21.7% vs. 5.2%, P = 0.028), were more frequently reported in patients with T2DM than in those without. Patients with T2DM showed a greater percentage of follow-up time in manic episodes (r = −0.23, P = 0.020) and a higher rate of manic episode(s) during follow-up (21.7% vs. 5.2%, P = 0.028) than those without. When restricting longitudinal analyses to patients with bipolar spectrum disorders, results were confirmed. In line with the well-known connection between BD and metabolic disorders, our data support an association between T2DM and unfavorable course of illness in the elderly with BD.

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Section: Discussionmentioning

confidence: 99%