A rare presentation of perforated carcinoma of colon as an anterior abdominal wall abscess—a case report and review of literature

Basukala, Sunil; Thapa, Narayan; Rayamajhi, Bikash Bahadur; Basukala, Bikram; Mandal, Pankaj Kumar; Karki, Bibek

doi:10.1093/jscr/rjab344

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Colon tumors can mimic abdominal diseases, with a broad spectrum of symptoms. The incidence of colorectal cancer perforation is 2.6%–7.8%, which is a rare case ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Xiang

Chen

et al. 2023

Front. Oncol.

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In recent years, although new drugs and molecular markers have been used to treat metastatic colorectal cancer, there has been little progress in the immunotherapy of advanced colon cancer. The development of sequencing and multiomics technology helps us classify patients more accurately, and then find patients who may benefit from immunotherapy. The development of this advanced technology and immunotherapy based on new targets may herald a new era in the treatment of metastatic colorectal cancer. It is well known that colorectal cancer with dmmr/msi-h phenotype is sensitive to immunotherapy, yet the POLE mutation is the MSS phenotype in colorectal tumors but is also an effective target for immunotherapy. This paper describes a case of recurrent intestinal leakage that required multiple surgical procedures. A high-grade colon adenocarcinoma was identified on surgical histopathology after 18 months, and bevacizumab combined with oxaliplatin and capecitabine proved ineffective against this cancer. An analysis of gene expression indicated that POLE (P286R) mutation, TMB 119.333 mutation per 100 MB, and immune checkpoint inhibitor treatment had a significant impact. This case reminds us that the existence of malignant tumors should be considered for patients with repeated intestinal leakage, and emphasizes the importance of gene detection in the treatment of malignant tumors and the significance of POLE mutations in colorectal cancer.

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“…Colon tumors can mimic abdominal diseases, with a broad spectrum of symptoms. The incidence of colorectal cancer perforation is 2.6%–7.8%, which is a rare case ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Xiang

Chen

et al. 2023

Front. Oncol.

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“…Patients with CRC commonly present to the outpatient setting with changes in bowel habit, rectal bleeding or iron deficiency anemia whereas up to one third can present to the emergency department with complications like perforation and obstruction. Colon carcinoma can mimic any abdominal disease with a wide spectrum of presentations [13] . However rare, perforation in CRC may lead to a localized collection intra abdominally and spread superficially into the skin creating a fistulous tract.…”

Section: Clinical Discussionmentioning

confidence: 99%

“…Adequate nutritional care and infection prophylaxis of the CCF allowed early recovery after surgery. Preoperative diagnosis of an underlying colonic carcinoma is challenging whereas treatment may be incomplete if an inaccurate diagnosis without the recognition of the underlying malignancy [13] . Colon cancer generally requires surgical resection of the tumor with appropriate delay to allow healing of fistulous tract.…”

Section: Clinical Discussionmentioning

confidence: 99%

Colorectal carcinoma presenting as spontaneous colocutaneous fistula - A rare case report and review of literature

Basukala

Khand²,

Pahari³

et al. 2022

International Journal of Surgery Case Reports

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An unusual initial presentation of colorectal cancer: abdominal wall and scrotal abscess associated with right ventricular metastasisAn unusual initial presentation of colorectal cancer: abdominal wall and scrotal abscess associated with right ventricular metastasis

Barakat

2024

Emerg Care J

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A 56-year-old man presented to the emergency department with a painful abdominal lump with redness of the overlying skin in the right iliac fossa, swelling, and redness of the scrotum. Laboratory tests revealed a marked increase in white blood cell count (50.73x109/L), neutrophil count (48.18x109/L), and C-reactive protein levels (37.36 mg/dL). Abdominal contrast-enhanced Computed Tomography (CT) scan showed a voluminous neoplastic lesion involving the ascending colon, the cecum, and the last ileal loop, which was in communication with a large abscess located in the anterior abdominal wall and extended craniocaudal up to the right scrotum; a mass within the right ventricle was also seen. The patient underwent a right hemicolectomy and a right orchiectomy. Histological examination revealed a low-grade mucinous adenocarcinoma of the right colon as well as a significant abscess of the right testis' tunica vaginalis. The patient died one month after surgery.

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A rare presentation of perforated carcinoma of colon as an anterior abdominal wall abscess—a case report and review of literature

Cited by 4 publications

References 10 publications

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment

Colorectal carcinoma presenting as spontaneous colocutaneous fistula - A rare case report and review of literature

An unusual initial presentation of colorectal cancer: abdominal wall and scrotal abscess associated with right ventricular metastasisAn unusual initial presentation of colorectal cancer: abdominal wall and scrotal abscess associated with right ventricular metastasis

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