A rare presentation of Sacrococcygeal Teratoma as recurrent natal cleft abscess in childhood

Cinelli, Daniel Pasquale; Stoica, Ionica; Atwan, Fadi; Paran, Sri

doi:10.1016/j.epsc.2020.101727

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A prior publication from our institution describes a case in which a patient suffered recurrent natal cleft abscesses and was ultimately diagnosed with a type IV SCT. 10 Second, we propose that type IV lesions may be more common than is currently thought (►Table 4). In Peter Altman's original study of 405 patients in 1974, type IV lesions were present in 10% of cases.…”

Section: Discussionmentioning

confidence: 93%

The Irish Experience with Sacrococcygeal Teratomas: Are Type IV Lesions More Common than We Think?

Kane,

Mortell,

Gillick

et al. 2023

Eur J Pediatr Surg

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Title The Irish experience with Sacrococcygeal Teratomas- are type IV lesions more common than we think? Introduction Sacrococcygeal Teratomas (SCT) are rare tumours occurring in approximately 1 in 35,000 to 40,000 live births. The Altman classification is used to describe SCTs. There are four types, with type 1 predominantly external through to type IV which is a presacral, completely internal mass. As far as the authors are aware, this is the first study to focus on Type IV SCT lesions. Materials and Methods Using ICD-10-AM codes, we identified all patients in the Republic of Ireland with a diagnosis of Sacrococcygeal Teratoma from 2004-2020. The following information was obtained for each patient; gender, time of diagnosis, clinical presentation, method of diagnosis, Altman classification, biomarkers, age at operation, surgical technique, pathology, recurrence, age at most recent follow-up. Results There were 29 patients in total; 23 Females (79%) and 6 males (21%). 16 (55%) were diagnosed antenatally, 4 (14%) at <1 month, 4 (14%) <1 year, 3 (10%) age 2-4 years and 2(7%) were aged 5-12 years. 22 (76%) were Mature Teratomas, 2 (7%) immature teratomas and 5 (17%) were Malignant tumours. There were 6 (21%) Type I lesions, 9 (30%) Type II, 6 (21%) Type III and 8 (28%) Type IV lesions. Conclusions In Altman’s original 1974 study, type IV lesions were present in 10% of cases. As a result, this is the most frequently quoted figure. Type IV lesions were present in 28% of cases in our study. We propose that type IV lesions may be more common than the current literature suggests and consequently a higher index of suspicion of their presence should be entertained.

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Section: Discussionmentioning

confidence: 93%

The Irish Experience with Sacrococcygeal Teratomas: Are Type IV Lesions More Common than We Think?

Kane,

Mortell,

Gillick

et al. 2023

Eur J Pediatr Surg

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“…[41] At the end of the caudal region of all embryos, there was a regression of the Hensen's node, demonstrating that there was no persistence of the primitive line. According to Cinelli et al [42] when the primitive line does not regress properly, a rare tumor is formed at the base of the coccyx, called sacrococcygeal teratoma, which contains derivatives from the three germ layers. The presence of this tumor in the postnatal period can compromise the intestinal and urological functions and cause eventual difficulties in locomotion, which justifies the investigation of the effects of yangambin on the primitive line.…”

Section: Resultsmentioning

confidence: 99%

Embryotoxicity of Yangambin Isolated from Ocotea duckei Vattimo-Gil in Gallus gallus domesticus Embryos

Silva¹,

Castro²,

Lucena³

et al. 2021

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Introduction: Yangambin, a lignan predominant in the leaves of Ocotea duckei Vattimo-Gil, has several biological activities, such as anti-convulsant, analgesic, anti-inflammatory and leishmanicidal. Objectives: The aim of this study was to evaluate the embryotoxicity of yangambin on the neurodevelopment of Gallus gallus domesticus embryos. Materials and Methods: 120 fertilized eggs were divided in three groups: G1 (PBS with 0.1 % Tween 80), G2 (50 µg/ml yangambin) and G3 (65 µg/ml yangambin) and each egg was inoculated with 100 µL of the respective solutions. The fertilized eggs were incubated at a temperature of 37.5°C, with a relative humidity of 65% to 75%, for 48 hr and then their embryos were histologically processed. Results: In staging, carried out according to Hamburger and Hamilton (1951), variations of stages were identified. In all groups, the morphological analysis revealed the closure of the anterior neuropore and absence of malformations in the optic vesicles and in the secondary encephalic vesicles. In the caudal region, a standard development of the neural tube was observed, with well-segmented somites and regression of the primitive line. The cross sections showed that the internal structure of the somite's, composed of dermatome, myotome and sclerotome, was preserved. The statistical analysis did not show significant differences between the groups regarding the morphometry of the cephalic and caudal regions of the neural tube. Conclusion: Yangambin did not show embryotoxic effects on the neurodevelopment of Gallus gallus domesticus embryos, under the tested conditions.

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Antenatal and histological diagnostics of cystic sacrococcygeal teratoma. Clinical case and literature review

Savukynė

Krzconaviciute

Vaitkeviciute

et al. 2023

Case Reports in Perinatal Medicine

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Objectives The congenital embryonic tumor known as sacrococcygeal teratoma (SCT) affects 1 in 35.000–40.000 newborns and is more prevalent in female fetuses and neonates. A total of 25–50% of SCTs are diagnosed by an ultrasound (US) examination during the second trimester of pregnancy. Planning the manner of delivery, determining the risk of negative outcomes, and choosing treatment options depend on the results of antenatal differential diagnosis. Case presentation This is a unique case of a 29-year-old second gravida, suspected of having a fetal sacrococcygeal dysplasia differentiable between Type 2 SCT and terminal myelocystocele. An MRI revealed no typical SCT changes, as a matter of course, the diagnosis of myelocystocele could not have been excluded. The results of the genetic examination allowed to exclude the chromosomal pathology. Punctuation of the external component of the formation and a cytological examination were suggested. Nevertheless, the patient and her partner refused further studies and insisted on the termination of pregnancy. Medical abortion was induced and histological findings confirmed fetal morphology to be mature SCT. Conclusions Cystic sacrococcygeal teratoma is an unusual malformation of fetal development. In the antenatal period SCT is diagnosed based upon an ultrasound evaluation, an MRI, and a multidisciplinary assessment of clinical experts. Differential diagnosis based upon clinical imaging during the gestational period is elaborate. The final medical diagnosis needs to be verified by a histological evaluation of pathological tissue. An antenatal medical diagnosis of fetal dysplasia is considerable for the further prognosis of fetal and newborn development.

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A rare presentation of Sacrococcygeal Teratoma as recurrent natal cleft abscess in childhood

Cited by 3 publications

References 7 publications

The Irish Experience with Sacrococcygeal Teratomas: Are Type IV Lesions More Common than We Think?

The Irish Experience with Sacrococcygeal Teratomas: Are Type IV Lesions More Common than We Think?

Embryotoxicity of Yangambin Isolated from Ocotea duckei Vattimo-Gil in Gallus gallus domesticus Embryos

Antenatal and histological diagnostics of cystic sacrococcygeal teratoma. Clinical case and literature review

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