A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review

Bennani, Amal; Fatemi, Hinde El; Souaf, Ihsane; Moumna, Kaoutar; Amarti, A.

doi:10.1186/1746-1596-8-36

Cited by 23 publications

(34 citation statements)

References 15 publications

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“…Other clinical symptoms include: hoarseness (35%), dyspnea (65%) and dysphagia (53%) [28]. HL of the thyroid may present as diffuse involvement of the gland or a focal lesion [29]. Both our patients presented enlargement of neck lymph nodes and the second one also has been complaining about hoarseness.…”

Section: Discussionmentioning

confidence: 95%

“…Differential diagnosis of thyroid lesions should also comprise other uncommon primary thyroid tumors. Leiomyosarcomas of the thyroid account for 6% of the all head and neck tumors, with 18 cases described so far in the world literature [29]. Primary squamous cell carcinoma (SCC) of the thyroid is also an extremely rare entity, observed in less than 1% of all thyroid malignancies [30].…”

Section: Discussionmentioning

confidence: 99%

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Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

et al. 2013

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Lymphomas account for less than 5% of thyroid malignant lesions. Vast majority of them are B-cell non-Hodgkin lymphomas (NHL), while Hodgkin lymphoma (HL) is extremely rare. Here we present two cases of HL, at baseline manifesting as a thyroid lesion. First patient, 29-year-old pregnant female, initially suspected for metastatic medullary thyroid cancer, was eventually diagnosed with mixed cellularity type of thyroid HL. Second patient, 22-year-old woman with suspicion of advanced thyroid cancer, was in the end diagnosed with an extra-lymphatic classical HL of the thyroid. In both cases, despite repeated fine-needle aspiration biopsy, cytological examination gave inconclusive or misleading results. On histopathological examination, thyroid tumor cells were positive for CD15 and CD30 antigen, which is typical for Reed-Sternberg cells. In the report authors also discuss difficulties in management as well as potential importance of novel methods such as FISH, PCR and other molecular techniques in diagnostics of thyroid lymphomas.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2896947559559648

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

et al. 2013

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“…The diagnosis of thyroid LMS requires comprehensive evaluation along with imaging and the assessment of clinical symptoms and immunohistochemical markers. The diagnosis can only be con rmed upon a lack of evidence regarding epithelial differentiation or other types of sarcoma differentiation and when immunohistochemistry yields positive smooth muscle markers [2].…”

Section: Introductionmentioning

confidence: 99%

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Hao

Huang

Tian

et al. 2020

Preprint

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Background Primary thyroid leiomyosarcoma(LMS) is very rare, with only 30 cases reported worldwide. Thyroid LMS should be diagnosed with caution and comprehensively evaluated considering clinical, imaging, and pathological data. It is a kind of fatal tumor with an extremely poor prognosis and lacks effective treatment regimens, and most patients die within 1 year of diagnosis. Here, we present a case report on a patient with Primary thyroid LMS. Case presentation A 76-year-old woman presented with hoarseness, dysphagia, and dyspnea when lying down for the past 1 month visited our hospital. She had a history of right neck masses in the past 2 years. A hard, irregular tumor of approximately 8 cm × 5 cm × 5 cm was observed on the right lobe of the thyroid, the boundary between which and the surrounding tissues was unclear. The tumor anteriorly invaded the cervical muscles and interiorly invaded the right walls of the trachea and esophagus. Most tumor tissues were excised, a curative operation seemed impossible. Immunohistochemically, the tumor cells were positive for Calponin, vimentin and SMA, but negative for EMA, CK, P53, Desmin and S-100. Tumor recurrence and progression were considered two months after surgery, the patient refused follow-up treatment for personal reasons and died 4 months after surgery. Conclusion Thyroid LMS accounting for merely 0.014% of primary thyroid tumors of unknown etiology. The diagnosis can only be confirmed upon a lack of evidence regarding epithelial differentiation or other types of sarcoma differentiation and when immunohistochemistry yields positive smooth muscle markers. Primary thyroid LMS is primarily surgically resected and no other effective treatment currently available. Disease progression is rapid, the prognosis is poor, and the 1-year survival rate is <10%. In the present study, a rare case of a 76-year-old female patient diagnosed with thyroid LMS was reported and a review of the literature is presented.

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“…Sarcomas are thought to originate from the wall of blood vessels [1]. The etiology of primary thyroid leiomyosarcomas remains unclear, however, certain authors have postulated that it may originate from the smooth muscle in the vascular walls (7,10,(11)(12)(13). They account for 6% of the head and neck tumours, of which only 0.014% of Leiomyosarcomas cases develop in the thyroid gland (7,8,9,10,13,14), with an estimated 1year survival rate of 5-10% (10,12).Primary thyroid leiomyosarcomais an extremely rare soft tissue cancer.…”

Section: Introductionmentioning

confidence: 99%

Leiomyosarcoma : Case Report of a Rare Primary Smooth Muscle Tumour of the Thyroid Gland

Kothari¹,

Godkhindi²,

Shetty³

et al. 2017

Journal of Health and Allied Sciences NU

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Primary smooth muscle tumours of the thyroid gland are extremely rare neoplasms. There are concerns regarding the management of such disease due to its rarity. Around 22 cases have been reported in the literature till date. In this study, the case of a 63year old female patient who presented with a rapidly enlarging anterior neck mass over the period of 3 months is reported. The patient underwent thyroidectomy with tracheostomy and radiotherapy for the treatment of primary leiomyosarcoma of thyroid gland. Due to similar clinical presentation as anaplastic carcinoma, diagnosis of primary thyroid leiomyosarcomas is difficult and maybe misdiagnosed. Hence the combined assessment of clinical, imaging and pathological data is required.Immunohistochemical analysis is a gold standard for diagnosis. Diagnosis and treatment of the current patient with primary thyroid leiomyosarcomaand a comprehensive review of the relevant literature are presented herein

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A rare primary tumor of the thyroid gland: report a new case of leiomyosarcoma and literature review

Cited by 23 publications

References 15 publications

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

Thyroid nodule as a first manifestation of Hodgkin lymphoma–report of two cases and literature review

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Leiomyosarcoma : Case Report of a Rare Primary Smooth Muscle Tumour of the Thyroid Gland

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