A rare recurrence of bilateral breast cancer in the esophagus coincidentally associated with primary gastric cancer: a case report

Kashiwagi, Shinichiro; Onoda, Naoyoshi; Asano, Yuka; Noda, Shinichi; Kawajiri, Hidemi; Takashima, Tsutomu; Ishikawa, Tetsuro; Hirakawa, Kosei

doi:10.1186/1752-1947-8-58

Cited by 3 publications

(6 citation statements)

References 18 publications

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“…In esophageal metastases, cancer cells are frequently found only within the esophageal wall, and the mucosal surface is not involved. Thus, the esophagography and endoscopy findings are characterized by regular, smooth stenosis of the esophagus [10]. These features were also found in our case.…”

Section: Discussionmentioning

confidence: 51%

“…In particular, esophageal metastasis occurs extremely rare [6][7][8][9][10][11]. In a previous study of more than 2,000 patients with breast cancer, the incidence of esophageal metastasis was only 0.4 % [12].…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer metastasis to the gastrointestinal (GI) tract is relatively rare [2][3][4][5]. In particular, metastasis to the esophagus is extremely rare [6][7][8][9][10][11]. A previous observational study involving more than 2000 patients with breast cancer revealed an incidence of esophageal metastasis of only 0.4 % [12].…”

Section: Introductionmentioning

confidence: 99%

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Breast cancer recurrence in esophagus, stomach, and liver, 15 years following primary surgery: report of a case

et al. 2014

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Metastasis of breast cancer to the gastrointestinal tract is relatively rare. We hereby report a case of breast cancer recurrence in the esophagus, stomach, and liver, 15 years following primary surgery. A 67-year-old woman presented with a 2-month history of dysphagia. Fifteen years previously, she had undergone right mastectomy for breast carcinoma. Upper gastrointestinal endoscopy revealed circumferential stenosis without mucosal abnormality in the lower esophagus and enlarged gastric folds and defective extension in the upper stomach. Biopsy specimens from the esophagus and gastric folds were consistent with invasive lobular carcinoma. Abdominal computed tomography and magnetic resonance imaging showed two hepatic tumors, and liver biopsy revealed breast cancer recurrence. Immunohistochemistry supported the diagnosis of breast cancer recurrence in the esophagus, stomach, and liver. Gastrointestinal metastases should be considered for patients with breast cancer who present with gastrointestinal symptoms, even if the primary tumor was treated many years previously.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Breast cancer recurrence in esophagus, stomach, and liver, 15 years following primary surgery: report of a case

et al. 2014

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“…Distant metastasis of breast cancer is commonly found in the bones, liver, lungs, and brain, whereas neck and esophageal metastasis is very rare (accounting for only around 0.5%) [ 4 ]. Lobular cancer is a histological type of breast cancer that frequently metastasizes into the gastrointestinal system, particularly to the stomach and colon [ 4 , 9 ]. We report a rare case of metastatic ductal carcinoma of the breast in a young woman with Horner’s syndrome and infiltration to the esophagus.…”

Section: Discussionmentioning

confidence: 99%

Concurrent manifestations of Horner’s syndrome and esophageal metastasis of breast cancer: case report of a young woman after a period of non-adherence to treatment: a case report

et al. 2021

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Background Esophageal involvement and Horner’s syndrome are rare manifestations of breast cancer distant metastases that can pose a significant challenge in diagnosis and treatment. In addition to the more aggressive behavior of breast cancer diagnosed in young women, non-adherence to treatment is associated with increased risk of distant metastasis. Case presentation A 36-year-old Javanese woman presented to our institution with dysphagia, hoarseness, and frequent hiccups. In the 6 weeks prior to the current admission, the patient also reported tingling in the neck and shoulder, anhidrosis in the left hemifacial region, and drooping of the upper left eyelid. She was previously managed as tuberculoid laryngitis. Plain X-rays showed burst fractures of the cervical vertebrae and slight pleural effusion. Laryngoscopy revealed bowing of the vocal cords and liquid residue in the vallecula that was reduced upon chin tuck. Esophageal metastasis was confirmed with endoscopy showing thickening of the wall and positive cytology swab with ductal malignant cells. The patient had a history of breast cancer with a period of loss to follow-up of 4 years. Conclusions Physicians should consider potential distant metastasis of breast cancer to the esophagus and sympathetic nervous system of the neck particularly in a high-risk woman with presentation of dysphagia and manifestations of Horner’s syndrome.

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“…There have been few case reports of metastasis of the breast cancer to the esophagus and vice versa [ 10 , 11 ] or metachronous esophageal cancer developing after radiation therapy for primary breast cancer [ 12 , 13 ]. However, synchronous double cancer of the esophagus and breast is very rare, and only one case has been reported to our knowledge [ 4 ].…”

Section: Case Presentationmentioning

confidence: 99%

Successfully treated advanced esophageal cancer with left axillary lymph node metastasis and synchronous right breast cancer: a case report

et al. 2015

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The incidence of double cancer of the esophagus and breast is rare, and axillary lymph node metastasis (ALM) in esophageal cancer is also very rare. We report a case of advanced esophageal cancer with left ALM and synchronous right breast cancer. A 64-year-old woman was admitted to our hospital with dysphagia. The clinical diagnosis was esophageal cancer (T3N0M1 stage IV) and right breast cancer (T1cN0M0 stage I). She was initially treated with triple chemotherapy with docetaxel, cisplatin, and 5-fluorouracil. The primary lesion in the esophagus achieved almost complete response as assessed by esophageal endoscopy. A computed tomography scan showed that the left ALM reduced in size and that stable disease was achieved for the right breast cancer. She underwent partial mastectomy of the right breast and bilateral axillary lymph node dissection. The histopathological diagnosis of the breast cancer was T1cN1M0 stage IIA. The lymph nodes from the left axilla contained metastatic cells from the squamous cell carcinoma of the esophagus. Complete response was achieved for the primary lesion in the esophagus following chemoradiotherapy (CRT), and the patient has been relapse free 2 years after treatment. Thus, we report the successful treatment of synchronous double cancers of the esophagus with left ALM and right breast by combination therapy with chemotherapy, CRT, and surgery.

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A rare recurrence of bilateral breast cancer in the esophagus coincidentally associated with primary gastric cancer: a case report

Cited by 3 publications

References 18 publications

Breast cancer recurrence in esophagus, stomach, and liver, 15 years following primary surgery: report of a case

Breast cancer recurrence in esophagus, stomach, and liver, 15 years following primary surgery: report of a case

Concurrent manifestations of Horner’s syndrome and esophageal metastasis of breast cancer: case report of a young woman after a period of non-adherence to treatment: a case report

Successfully treated advanced esophageal cancer with left axillary lymph node metastasis and synchronous right breast cancer: a case report

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