A rare skin disorder associated with a stoma: intestinal metaplasia and adenoma occurring in a skin ulcer around a colostomy site

Miida, Hiroshi; Wakaki, Kunihiko; Shimoda, Satoshi

doi:10.1111/ijd.14506

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Foci of intestinal metaplasia in other organs can develop adenomatous and precancerous changes. 14 Therefore, cutaneous intestinal metaplasia could a priori undergo similar changes and become malignant. However, there was no significant atypia in the intestinal epithelium of our biopsy, and we did not find any mitoses either.…”

Section: Discussionmentioning

confidence: 99%

Primary Idiopathic Cutaneous Intestinal Metaplasia: First Case

Fernández-Flores

2021

The American Journal of Dermatopathology

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Cutaneous intestinal either metaplasia or ectopia has mostly been described around intestinal stomas or in patients with Crohn disease. In this study, we described a unique case of cutaneous metaplasia on the elbow of a 25-year-old man who had a clinical history of epidermolysis bullosa simplex, but had no history of any gastrointestinal disease. The lesion had been clinically stable for 5 years. Histopathologically, the epithelium showed many columnar cells with mucinous cytoplasm, with no atypia or mitoses. The proliferation rate was low (7% by Ki67). The metaplastic areas expressed epithelial membrane antigen, carcinoembryonic antigen, cytokeratin 7, MUC5AC, MUC2, and Cyclin-D1.

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Section: Discussionmentioning

confidence: 99%

Primary Idiopathic Cutaneous Intestinal Metaplasia: First Case

Fernández-Flores

2021

The American Journal of Dermatopathology

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“…Although rare, some of the reported cases of intestinal metaplasia along ostomy sites have displayed concomitant adenoma or dysplasia in cases of peristomal adenocarcinoma and/or squamous cell carcinoma . As such, close clinical monitoring is imperative to identify malignancy early and improve patient morbidity/mortality rates.…”

Section: Discussionmentioning

confidence: 99%

“…1,5 Although rare, some of the reported cases of intestinal metaplasia along ostomy sites have displayed concomitant adenoma or dysplasia in cases of peristomal adenocarcinoma and/or squamous cell carcinoma. 5,7,8 As such, close clinical monitoring is imperative to identify malignancy early and improve patient morbidity/mortality rates. Clinical presenting symptoms reported in patients with ileostomy carcinomas include palpated mass, small bowel obstruction, peristomal bleeding, pain, stomal prolapse, or retraction.…”

Section: Discussionmentioning

confidence: 99%

A case of periostomy intestinal metaplasia without adenomatous or dysplastic changes in an ulcerative colitis patient

Udechukwu

Selim

Nicholas

2020

Clinical Case Reports

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“…Cutaneous intestinal metaplasia is a rare ostomy-related complication, and all reported cases have been associated with colostomies or ileostomies for stool collection. [ 1 2 ] Metaplastic nodules can occur even after ostomy reversal. [ 3 ] Theoretically, cutaneous intestinal metaplasia occurs at the urostomy site, where the ileal conduit is directly connected to the epidermis.…”

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confidence: 99%

“…Such a nodule is usually reported as an adenomatous change with over-granulation tissue. [ 2 ] Adenocarcinomas have also been reported as peristomal nodules, especially in patients with inflammatory bowel syndrome and gastrointestinal polyposis. [ 5 ] The present case is unusual because the papillomatous protrusions appeared without erosions or ulcers, which could easily have led to its clinical misdiagnosis as a viral wart.…”

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confidence: 99%