A rare t(4;12)(q12;p13) in an adolescent patient with acute myeloid leukemia

Acute myeloid leukemia with t(4;12)(q12;p13): report of 2 cases

“…Other common characteristics, such as CD7 expression, negative myeloperoxidase activity, and failure of the first induction chemotherapy were observed in the first case. As in previous reports, intensive treatment or hematopoietic stem cell transplantation were curative [ 5 7 ]. In the second case, t(4;12) presented as a single abnormality, which showed development of a subclone with a 7q deletion as the disease progressed.…”

“…The translocation presented as either a single chromosomal abnormality or combined with other abnormalities ( Table 1 ) [ 1 3 4 5 6 7 8 10 11 12 13 14 15 ]. The karyotype of the first patient was 46,XY, t(4;12)(q12;p13),del(5)(q22q35), and del(5q) is a common chromosomal abnormality in myelodysplastic syndrome and in AML with myelodysplasia-related changes.…”

“…TO THE EDITOR: Acute myeloid leukemia (AML) with t(4;12) is rare, but its unique morphologic and clinical characteristics have been described in several reports [ 1 2 3 4 5 6 7 8 ]. Most cases show CD7 expression, low or absent myeloperoxidase activity, basophilia, unique blast morphology, dysplastic features, and poor prognosis [ 1 2 3 4 5 6 7 8 ]. Harada et al reported that the incidence among adults is 0.6% [ 1 2 ].…”

A new case of t(4;12)(q12;p13) in a secondary acute myeloid leukemia with review of literature

“…The male to female ratio is 1.5:1 (1.7:1 in adults and 1:1 in children). The majority of patients are adults, aged 18 to 82 with the mean being 58.9 years old (Harada et al, 1995;Harada et al, 1997;Ma et al, 1997;Cools et al, 1999;Hamaguchi et al, 1999;Chaufaille et al, 2003;Manabe et al, 2010). Four children have been reported, aged 3-14 years old, of which three had ALL and the oldest had AML (Harada et al, 1997).…”

“…Previous reports suggest that less than 50% of cases achieve remission with intensive induction chemotherapy. Of the patients who do not achieve morphologic remission, none survived beyond six months (Hamaguchi et al, 1999;Chaufaille et al, 2003;Manabe et al, 2010). The breakpoint at 12p13 in t(4;12) AML is located within or near the ETV6 gene locus.…”