A Rarity in Breast Disease: Metastatic Ovarian Carcinoma to the Breast Mimicking Inflammatory Breast Cancer

Attrache, Ben Fauzi El; Highsmith, Camryn; Gluck, Bradley; Kapenhas, Alan Heimann Edna

doi:10.21767/2254-6758.100081

Cited by 3 publications

(5 citation statements)

References 2 publications

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“…The incidence of ovarian cancer metastatic to the breast or axillary lymph nodes is extremely low, 0.03–0.6%. The first case was reported in 1907 and only over 110 cases have been described until 2015 [40,41]. The pathophysiological mechanisms of these metastases suggest a hematogenous or lymphatic pattern of spread.…”

Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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Background: Although metastases of ovarian and peritoneal carcinomatosis are most commonly found within the peritoneal cavity, there is a number of other rare distant sites that have been reported. Our goal is to provide an evidence-based summary of the available literature considering the rare distant metastatic sites of ovarian and peritoneal carcinomatosis. Methods: A comprehensive search of the literature was conducted, with Medline/PubMed being searched for cases of rare metastatic disease originated from primary ovarian and peritoneal cancer with related articles up to 2019 including terms such as “ovarian cancer”, “metastases”, “peritoneal” and others. Results: The most common mechanism of ovarian cancer metastases consists of primarily dissemination within the peritoneal cavity, while, rare and distant sites can either occur at the beginning or during the course of the disease and they are usually associated with hematogenous route and lymphatic invasion, having poor prognosis, with the least common sites being skin, bone, CNS, eye, placenta, central airways, rare lymph nodes, intra-abdominal organs, heart and breast. Conclusions: The occurrence of metastatic sites described in this review represents the most common rare distant metastatic sites, and even though their patterns of metastases are still not fully clarified due to the rarity of the reports, they offer valuable information considering the pathophysiology of the disease.

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Section: Pathways and Metastatic Sites Of Ovarian And Peritoneal Cmentioning

confidence: 99%

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Thomakos

Diakosavvas

Machairiotis

et al. 2019

Cancers

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“…Metastases to the breast and the axillary lymph nodes are very rare in primary ovarian malignancy with an incidence of only 0.03%–0.06%[ 9 ] and serious papillary carcinoma is the most common type. [ 12 , 13 ] Route of dissemination may be lymphatic or hematogenous; generally, these lesions are circumscribed masses, while in lymphatic diffuse breast involvement will be there.…”

Section: Discussionmentioning

confidence: 99%

“…The overall survival after diagnosis of skin metastasis ranges from 2 to 65 months. [ 7 ] Intrathoracic lymph node involvement is very rare and found in 2.3%,[ 8 ] and axillary lymph node metastasis without breast cancer is extremely low (0.03%–0.6%),[ 9 ] and only 110 cases have been described until 2015. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Skin Metastases in Ovarian Malignancy: A Case Report with Literature Review

Pipal

Singh

Pipal

et al. 2023

Journal of Mid-Life Health

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Ovarian cancer is the most lethal gynecologic malignancy, mostly diagnosed in the advanced stage with multiple sites of metastases. Routes of spread are direct through exfoliation, lymphatic channels, and less commonly hematogenous spread. Skin metastasis in ovarian malignancy is a rare occurence, its incidence range from 1.9% to 5.1% and the most common sites are the abdominal wall and chest wall. The incidence of metastasis to breast and/or axillary lymph nodes is very rare, ranging from 0.03% to 0.6%. We report the case of a 60-year-old female with stage IV B undifferentiated ovarian carcinoma with multiple cutaneous metastases involving the skin over the left breast, scalp, and mediastinal lymph nodes, which are rare sites of metastases. The incidence of cutaneous metastasis in ovarian cancer is 1.9%–5.1% and the overall survival after diagnosis ranges from 2 to 65 months.

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“…Individual case reports of metastatic ovarian cancer to the breast demonstrate this most commonly occurs in the recurrent setting, up to 5 years following treatment ( Mori et al, 2017 , Patel et al, 2014 , Skagias et al, 2008 ). Cases of metastatic ovarian cancer presenting as inflammatory breast cancer have also been reported ( El Attrache et al, 2017 , Klein et al, 2010 ). Even more rarely, enlarged intermammary and axillary lymph nodes identified on routine screening mammography are the initial presentation of metastatic ovarian cancer ( Susini et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

“…Only 0.3–6.3% of malignant breast tumors originate from a solid tumor somewhere other than the breast ( Antuono et al, 2018 ). Ovarian cancer metastasizes to the breast very rarely, in only 0.03–0.6% of cases ( El Attrache et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography

Sobecki

Dryer

Mahajan

et al. 2021

Gynecologic Oncology Reports

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A Rarity in Breast Disease: Metastatic Ovarian Carcinoma to the Breast Mimicking Inflammatory Breast Cancer

Cited by 3 publications

References 2 publications

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature

Skin Metastases in Ovarian Malignancy: A Case Report with Literature Review

BRCA-2 (+) high-grade serous fallopian tube cancer diagnosed as an isolated breast mass by mammography

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