A rarity in breast pathology: First recurrent male case of Rosai-Dorfman disease

El-Attrache, BenFauzi; Gluck, Bradley; Heimann, Alan; Kapenhas, Edna

doi:10.1016/j.ijscr.2018.10.003

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Cited by 9 publications

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“…The RDD lesion demonstrates positivity of S100 and CD68, negativity of CD1a by immunohistochemical study. Current common treatment modality is surgical resection with rare recurrence [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

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2019

JGWH

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Rosai-Dorfman disease (RDD) is an idiopathic, benign proliferation of histiocytes that can be present in multiple organs such as lymph node, skin, soft tissue, orbit, central nerve system and bone; however, it rarely occurs in the breast. In general, RDD is a painless, firm and poorly defined lesion, which can radiologically mimic a breast cancer and is therefore an important consideration. The diagnosis of breast RDD is challenging, especially on a small biopsy specimen. We report a unique case of breast RDD with a literature review including common presentation, differential diagnosis, and recommended management. A high index of suspicion for this rare entity is essential to render a correct diagnosis, thereby avoiding unnecessary diagnostic tests and treatment.

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