A rat-friendly modification of the non-invasive tail-cuff to record blood pressure

Lipták, Boris; Kaprinay, Barbara; Gaspárová, Zdenka

doi:10.1038/laban.1272

Cited by 13 publications

(9 citation statements)

References 20 publications

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“…As proposed in our hypotheses, the rats with metabolic syndrome were found to have increased chances of malignant arrhythmia occurrence (29) and untreated animals in this experiment were most susceptible to arrhythmia (the HFFD-C group). HFFD-A and HFFD-SMe25 groups had reduced numbers of malignant arrhythmia records, while the lower dosage of the experimental SMe1EC2 had no pronounced effect.…”

Section: Discussionsupporting

confidence: 50%

Anti-arrhythmic and cardio-protective effects of atorvastatin and a potent pyridoindole derivative on isolated hearts from rats with metabolic syndrome

Lipták¹,

Knézl²,

Gaspárová³

2019

BLL

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OBJECTIVES: Aims of this study were to investigate the anti-arrhythmic and cardio-protective effect of atorvastatin and of a new pyridoindole derivative (SMe1EC2) on isolated and perfused hearts while following the Langendorff principles. BACKGROUND: Metabolic syndrome is a widely distributed condition progressing to cardiovascular disease. Many of the metabolic syndrome patients take (HMG)-co-enzyme A (CoA) reductase inhibitors with potential cardioprotective effects. SMe1EC2 is a promising new drug, exerting many positive effects in experimental settings. METHODS: Rats with induced metabolic syndrome were treated with atorvastatin (25 mg/kg) and SMe1EC2 (25 mg/kg and 0.5 mg/kg, respectively) daily for 3 weeks. After the treatment, the hearts were isolated and perfused according to Langendorff. RESULTS: Both atorvastatin and SMe1EC2 improved cardiac function by elevating the left ventricular developed pressure (VLDP) and cardiac contractility. Both SMe1EC2-treated groups improved LVDP during reperfusion, signifi cantly increased-dP/dt, and moderately elevated +dP/dt values. The treatment with both atorvastatin and SMe1EC2 (25 mg/kg) signifi cantly reduced malignant arrhythmia in comparison to control group and group treated with SMe1EC2 0.5 mg/kg. CONCLUSIONS: Owing to its anti-arrhythmic and cardio-protective effects, atorvastatin and SMe1EC2 could be of benefi t to patients suffering from metabolic syndrome (Tab.

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Section: Discussionsupporting

confidence: 50%

Anti-arrhythmic and cardio-protective effects of atorvastatin and a potent pyridoindole derivative on isolated hearts from rats with metabolic syndrome

Lipták¹,

Knézl²,

Gaspárová³

2019

BLL

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“…Blood pressure (BP) was recorded in a quiet and temperature‐controlled (22°C‐24°C) room to reduce ambient stress. We used the tail‐cuff method to measure the BP in conscious rats using a non‐invasive BP measurement system (Visitech BP‐2000, USA). Rats were habituated to the touch of a human hand and to the measuring tubes 1 week before initiation of the experiment.…”

Section: Methodsmentioning

confidence: 99%

Vascular calcification is associated with Wnt‐signaling pathway and blood pressure variability in chronic kidney disease rats

Liao

Wang

et al. 2019

Nephrology

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Aim Vascular calcification (VC) is a common complication in chronic kidney disease (CKD) and has been shown to be associated with increased cardiovascular events and mortality. This study was to explore the role of Wnt‐signaling pathway in CKD VC, and the association between VC and blood pressure variability (BPV) which is a risk factor of cardiovascular events. Methods Adult male Sprague‐Dawley rats were divided into adenine‐induced CKD group (n = 5), 5/6 nephrectomy CKD group (n = 5), sham group (n = 5) and control group (n = 5). Low‐calcium‐high‐phosphate diets were introduced to induce vascular calcification. Both daytime (hour‐to‐hour during the day) and mid‐term (day‐to‐day for 9 days) blood pressure (BP) were collected and analyzed for BPV metrics. At sacrifice, kidney, heart and aorta samples were taken for histological analyses. Calcium deposition in aorta was identified with Alizarin Red stain and graded. Immunohistochemistry stain and western blot were performed for Wnt3a, Wnt5a, β‐catenin, sclerostin, osteopontin, and α‐SMA. Results Compared with control rats, CKD rats suffered from markedly severer VC (Grade 2.6 ± 0.2 and 1.8 ± 0.8 vs 0.0 ± 0.0 and 0.2 ± 0.4, P = .0010). VC was positively correlated with vascular Wnt3a and β‐catenin expression (P = .0032 and .0000), but not significantly associated with Wnta5a or sclerostin. Besides, CKD rats showed increased BPV (P < .001), which was also positively correlated with VC. Conclusion We confirmed that CKD rats had enhanced Wnt‐signaling in vascular tissue and severer aorta calcification together with increased BPV. Wnt pathway may be a potential target in future VC and BPV management in CKD.

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“…We believe that this finding is relevant, although the issue of a "pathological scar" is unresolved. Third, we measured the blood pressure of spontaneously hypertensive and normotensive rats using a tail-cuff system because of its non-invasiveness, according to the previous studies on rat experiments [38][39]. However, the blood pressure measurement of rats using the telemetry system is a more precise and better method than the tail-cuff system.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-Converting Enzyme Inhibitor, Captopril, Improves Scar Healing in Hypertensive Rats

Rha¹,

Kim²,

Kim³

et al. 2021

Int. J. Med. Sci.

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A rat-friendly modification of the non-invasive tail-cuff to record blood pressure

Cited by 13 publications

References 20 publications

Anti-arrhythmic and cardio-protective effects of atorvastatin and a potent pyridoindole derivative on isolated hearts from rats with metabolic syndrome

Anti-arrhythmic and cardio-protective effects of atorvastatin and a potent pyridoindole derivative on isolated hearts from rats with metabolic syndrome

Vascular calcification is associated with Wnt‐signaling pathway and blood pressure variability in chronic kidney disease rats

Angiotensin-Converting Enzyme Inhibitor, Captopril, Improves Scar Healing in Hypertensive Rats

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