2001
DOI: 10.1046/j.1365-2672.2001.01399.x
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A rat model for dose-response relationships of Salmonella Enteritidis infection

Abstract: Aims:To develop an animal model to study dose±response relationships of enteropathogenic bacteria. Methods and Results: Adult, male Wistar Unilever rats were exposed orally to different doses of Salmonella enterica serovar Enteritidis after overnight starvation and neutralization of gastric acid by sodium bicarbonate. The spleen was the most sensitive and reproducible organ for detection of dose-dependent systemic infection. Illness was only observed in animals exposed to doses of 10 8 cfu or more. At lower do… Show more

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Cited by 46 publications
(47 citation statements)
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“…Enteritidis strains LA5 and S1400 colonized and invaded in a manner generally similar to that seen with other S. Enteritidis or S. Typhimurium strains (Naughton et al, 1995(Naughton et al, , 1996a(Naughton et al, , 2000Havelaar et al, 2001;Islam et al, 2000). Thus, there was rapid distribution throughout the gastrointestinal tract, translocation to the mesenteric lymph nodes and spread to the liver and spleen of the rats.…”
Section: Discussionmentioning
confidence: 58%
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“…Enteritidis strains LA5 and S1400 colonized and invaded in a manner generally similar to that seen with other S. Enteritidis or S. Typhimurium strains (Naughton et al, 1995(Naughton et al, , 1996a(Naughton et al, , 2000Havelaar et al, 2001;Islam et al, 2000). Thus, there was rapid distribution throughout the gastrointestinal tract, translocation to the mesenteric lymph nodes and spread to the liver and spleen of the rats.…”
Section: Discussionmentioning
confidence: 58%
“…Salmonella sp. colonize the whole gastrointestinal tract of the rat and cause disruption of the small intestine epithelium, epithelial cell hyperplasia and infiltration by inflammatory cells (Naughton et al, 1995(Naughton et al, , 1996a(Naughton et al, , 2000Havelaar et al, 2001;Islam et al, 2000). Invasion is mainly via the ileum; large numbers of salmonella reach the mesenteric lymph nodes and moderate numbers spread to and persist in the liver and spleen.…”
Section: Introductionmentioning
confidence: 99%
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“…However, many aspects, such as time-course effects of Salmonella colonization and translocation, are largely similar in this rat model compared with humans (3,5,15).…”
Section: Discussionmentioning
confidence: 88%
“…El bazo ha sido reportado como el órgano más sensible y útil para la detección de Salmonella enterica en infecciones sistémicas aislada en roedores (Havelaar et al, 2001 Además, se encontraron cepas resistentes a furazolidona (15.0%) y colistina (12.5%) entre otras. Por otro lado, el 42.5% de las cepas mostraron una susceptibilidad intermedia contra oxitetraciclina (Cuadro 1).…”
Section: Resultados Y Discusiónunclassified