A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide
Zhiping Hu,
Takeshi Kurihara,
Yiyue Sun
et al.
Abstract:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, and commonly associated with hepatic fibrosis or cirrhosis. This study aims to establish a rat model mimicking the progression from liver fibrosis to cirrhosis and subsequently to HCC using thioacetamide (TAA). We utilized male Lewis rats, treating them with intra-peritoneal injections of TAA. These rats received bi-weekly injections of either 200 mg/kg TAA or saline (as a control) over a period of 34 weeks. The development of cirrhosi… Show more
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