A ratiometric and colorimetric probe for detecting Hg<sup>2+</sup> based on naphthalimide–rhodamine and its staining function in cell imaging

Wang, Yuesong; Ding, Haichang; Wang, Shuai; Fan, Congbin; Tu, Yayi; Liu, Gang; Pu, Shouzhi

doi:10.1039/c9ra01459d

Cited by 21 publications

(9 citation statements)

References 43 publications

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“… 50 , 51 The detection limit was found to be 4.0 × 10 –8 M, which is smaller than that of previous Hg 2+ fluorescent probes. 19 , 22 , 35 , 52 − 54 The above results prove that probe 1 can be applied for quantitative determination of Hg 2+ .…”

Section: Resultssupporting

confidence: 57%

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Tian

Wang

et al. 2020

ACS Omega

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Hg 2+ has a significant hazardous impact on the environment and ecosystem. There is a great demand for new methods with high selectivity and sensitivity to determine mercury in life systems and environments. In this paper, a novel turn-on Hg 2+ fluorescent probe has been reported with a naphthalimide group. The Hg 2+ fluorescent probe was designed by the inspiration of the well-known specific Hg 2+ -triggered thioacetal deprotection reaction. A 1,2-dithioalkyl group was chosen as the specific recognition site of Hg 2+ . The probe showed weak fluorescence without Hg 2+ , and the color of the solution was light yellow. In the presence of Hg 2+ , the probe reacted specifically with the mercury ion to produce an aldehyde and emitted strong fluorescence, and the color of the solution also turned light green, thus realizing the monitoring of the mercury ion. The Hg 2+ fluorescent probe showed outstanding sensitivity and selectivity toward Hg 2+ . Furthermore, the Hg 2+ fluorescent probe could work in a wide pH range. The linear relationship between the fluorescence intensity at 510 nm and the concentration of Hg 2+ was obtained in a range of Hg 2+ concentration from 2.5 × 10 –7 to 1.0 × 10 –5 M. The detection limit was found to be 4.0 × 10 –8 M for Hg 2+ . Furthermore, with little cell toxicity, the probe was successfully applied to the confocal image of Hg 2+ in PC-12 cells.

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Section: Resultssupporting

confidence: 57%

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Tian

Wang

et al. 2020

ACS Omega

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“…1). According to the HMBC spectrum, H (7) correlates with C(10) but does not correlate with C(11), as a result, the orientation of the product must be in the case of structure IV which indicates the reaction yields in the formation of compound I.…”

Section: Methodsmentioning

confidence: 99%

“…With the help of the NMR results, we first assigned all the peaks in 1 H and 13 C NMR spectra using COSY and HMQC spectra. After successful assignments of all peaks, we then examine the HMBC spectrum to observe the heteronuclear correlation of the H (7) with C(10) and C (11). This correlation can distinguish two possible products from each other.…”

Section: Methodsmentioning

confidence: 99%

“…1), there must be a correlation of H (7) with C (10) and no any correlation with C(11). In the case of formation of structure V, there must be a correlation of H (7) with C(10) and C (11) in the HMBC spectrum (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…According to WHO's list concerning human health released in 2017, four heavy metals, including plum, cadmium, mercury and arsenic are listed as ten dangerous chemical substances or a combination of chemical products [5]. Among the heavy metals, mercury, with its high toxicity and bio-accumulative dissemination, is the most dangerous pollutant to be considered, because, Hg(II) damage the central nervous system, DNA, mitotic and endocrine system by blocking proteins, enzymes and membranes [6][7][8]. Mercury emission is caused by a variety of natural factors, including oceanic, volcanic, and anthropogenic influences such as gold mining and waste and fossil fuel combustion [9].…”

Section: Introductionmentioning

confidence: 99%

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A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Kaya

2021

Russ J Coord Chem

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Synthesis and photophysical investigation of Schiff base as a Mg²⁺ and Zn²⁺ fluorescent chemosensor and its application

Mei

wentao

et al. 2023

Luminescence

Self Cite

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In view of the fluorescent switching properties and anti-fatigue properties of diarylethene, a diarylethene fluorescent chemosensor for the immediate detection of zinc ion (Zn 2+ ) and magnesium ion (Mg 2+ ) in acetonitrile was synthesized in this article.The structure of 1o was determined by performing spectroscopy and elemental analysis. The presence of Zn 2+ or Mg 2+ made the chemosensor 1o show an obvious "turn-on" fluorescent signal (bright yellow-green for Mg 2+ and bright cyan for Zn 2+ ).The fluorescent change caused by the 1:1 binding of 1o and Zn 2+ or Mg 2+ might be due to hindering the excited-state intramolecular proton transfer (ESIPT) process, which were bolstered by Benesi-Hildebrand analysis, Job's plot curves, proton nuclear magnetic resonance ( 1 H-NMR) titration and mass spectrometry. The limits of detection were acquired from the standard curve plots for Mg 2+ at 44.6 nM and for Zn 2+ at 14 nM. Based on the fluorescent behaviors, a logic gate was constructed with the emission intensity at 528/518 nm as output signal, the ultraviolet-visible (UV-vis) lights, Mg 2+ /Zn 2+ and EDTA as input signals. Exogenous Zn 2+ and Mg 2+ fluorescent bioimaging were performed on Hela cells with 1o, indicating its potential application in biodiagnostic analysis. In particular, 1o was manufactured into test paper, and Zn 2+ or Mg 2+ can be conveniently, efficiently and qualitatively identified by the fluorescent color variation of the test strips.

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A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

Abstract: A new probe based on naphthalimide–rhodamine was applied in recognition of Hg2+ by a FRET mechanism.

Cited by 21 publications

References 43 publications

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Synthesis and photophysical investigation of Schiff base as a Mg²⁺ and Zn²⁺ fluorescent chemosensor and its application

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A ratiometric and colorimetric probe for detecting Hg2+ based on naphthalimide–rhodamine and its staining function in cell imaging

Abstract: A new probe based on naphthalimide–rhodamine was applied in recognition of Hg2+ by a FRET mechanism.

Cited by 21 publications

References 43 publications

A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Synthesis and photophysical investigation of Schiff base as a Mg2+ and Zn2+ fluorescent chemosensor and its application

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Product

Resources

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A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Synthesis and photophysical investigation of Schiff base as a Mg²⁺ and Zn²⁺ fluorescent chemosensor and its application