A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells

Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging

“…Having a quinoline pharmacophore on aminosteroid RM-581, we were interested in turning our anticancer agent into a fluorescent one (RM-581-Fluo; Figure ) by adding a small dimethyl amino group and using this opportunity to provide a new tool for RM-581 MoA studies. Also, considering the large number of quinoline-based anticancer agents, − a successful result could offer a relevant example for the use of such a fluorophore to support biological studies related to this class of pharmaceutical compounds.…”

Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

“…This field has been extensively reviewed by Huang. 82 Du reported a ratiometric fluorescent probe 83 for the detection of leucine aminopeptidase (LAP) based on a quinoline derived fluorophore for imaging LAP on liver tumour cells. The probe contained a galactose moiety for targeting active tumours and a caged quinolone.…”

Recent research progress in galactose-based fluorescent probes for detection of biomarkers of liver diseases

“…Various biomarkers fluctuate significantly with the progression of liver disease, which comprise proteins such as enzymes 24,25 and lectins; 26 reactive oxygen species (ROS) such as OH , ClO À , H 2 O 2 , etc. ; reactive nitrogen species (RNS) such as ONOO À and NO; reactive sulfur species (RSS) containing H 2 S; and biological thiols such as glutathione (GSH), cysteine (Cys), and some metal ions.…”